Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury
- PMID: 38892398
- PMCID: PMC11173246
- DOI: 10.3390/ijms25116211
Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury
Abstract
Myocardial infarction activates an intense fibro-inflammatory reaction that is essential for cardiac remodeling and heart failure (HF). Bioactive peptide galanin plays a critical role in regulating cardiovascular homeostasis; however, its specific functional relevance in post-infarction fibro-inflammatory reprogramming remains obscure. Here, we show that galanin coordinates the fibro-inflammatory trajectory and mitochondrial integrity in post-infarction reperfusion injury. Aberrant deposition of collagen was associated with a marked increase in CD68-positive macrophage infiltration in cardiac tissue in mice subjected to myocardial ischemia/reperfusion (I/R) for 14 days compared to sham controls. Furthermore, we found that the myocardial expression level of a specific marker of M2 macrophages, CD206, was significantly down-regulated in I/R-challenged mice. In contrast, galanin treatment started during the reperfusion phase blunted the fibro-inflammatory responses and promoted the expression of CD206 in I/R-remodeled hearts. In addition, we found that the anti-apoptotic and anti-hypertrophic effects of galanin were associated with the preservation of mitochondrial integrity and promotion of mitochondrial biogenesis. These findings depict galanin as a key arbitrator of fibro-inflammatory responses to cardiac I/R injury and offer a promising therapeutic trajectory for the treatment of post-infarct cardiovascular complications.
Keywords: apoptosis; cardiac remodeling; fibrosis; inflammation; mitochondria.
Conflict of interest statement
The authors declare no conflicts of interest.
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References
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- Osokina A., Karetnikova V., Polikutina O., Ivanova A., Gruzdeva O., Dyleva Y., Kokov A., Brel N., Pecherina T., Barbarash O. Prognostic potential of cardiac structural and functional parameters and N-terminal propeptide of type III procollagen in predicting cardiac fibrosis one year after myocardial infarction with preserved left ventricular ejection fraction. Aging. 2021;13:194–203. doi: 10.18632/aging.202495. - DOI - PMC - PubMed
-
- Ren Z., Yang K., Zhao M., Liu W., Zhang X., Chi J., Shi Z., Zhang X., Fu Y., Liu Y., et al. Calcium-Sensing Receptor on Neutrophil Promotes Myocardial Apoptosis and Fibrosis after Acute Myocardial Infarction via NLRP3 in Flammasome Activation. Can. J. Cardiol. 2020;36:893–905. doi: 10.1016/j.cjca.2019.09.026. - DOI - PubMed
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