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Review
. 2024 Jun 6;25(11):6272.
doi: 10.3390/ijms25116272.

Investigating Vitamin D-Binding Protein's Role in Childhood Health and Development

Charlotte Delrue  1 , Reinhart Speeckaert  2 , Joris R Delanghe  3 , Agnieszka Prytuła  4 , Marijn M Speeckaert  1   5
Affiliations
Review

Investigating Vitamin D-Binding Protein's Role in Childhood Health and Development

Charlotte Delrue et al. Int J Mol Sci. .

Abstract

Vitamin D-binding protein (DBP), also known as Gc-globulin, is a protein that affects several physiological processes, including the transport and regulation of vitamin D metabolites. Genetic polymorphisms in the DBP gene have a significant impact on vitamin D levels and may have implications for disease risk. DBP polymorphisms are linked to differential immune responses, which could influence the onset of juvenile diseases. This narrative review examines the various roles of DBP, with a focus on bone health, immunological regulation, and lipid metabolism in children. Chronic disorders affected by DBP polymorphisms include bone abnormalities, autoimmune diseases, cardiovascular issues, childhood asthma, allergies, cystic fibrosis, acute liver failure, celiac disease, inflammatory bowel disease, and chronic kidney disease. Future research should focus on identifying the processes that underpin the many roles that DBP plays and developing customized therapeutics to improve health outcomes in the juvenile population.

Keywords: children; polymorphisms; vitamin D-binding protein.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Role of vitamin D-binding protein (DBP) in vitamin D metabolism and bioavailability, and additional roles.
See this image and copyright information in PMC

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