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Observational Study
. 2024 May 23;16(11):1577.
doi: 10.3390/nu16111577.

Maternal Hypertriglyceridemia in Gestational Diabetes: A New Risk Factor?

Francisca Marques Puga  1 , Diana Borges Duarte  2 , Vânia Benido Silva  3 , Maria Teresa Pereira  1 , Susana Garrido  1 , Joana Vilaverde  1 , Marta Sales Moreira  4 , Fernando Pichel  5 , Clara Pinto  4 , Jorge Dores  1
Affiliations
Observational Study

Maternal Hypertriglyceridemia in Gestational Diabetes: A New Risk Factor?

Francisca Marques Puga et al. Nutrients. .

Abstract

Elevated maternal triglycerides (TGs) have been associated with excessive fetal growth. However, the role of maternal lipid profile is less studied in gestational diabetes mellitus (GDM). We aimed to study the association between maternal lipid profile in the third trimester and the risk for large-for-gestational-age (LGA) newborns in women with GDM. We performed an observational and retrospective study of pregnant women with GDM who underwent a lipid profile measurement during the third trimester. We applied a logistic regression model to assess predictors of LGA. A total of 100 singleton pregnant women with GDM and third-trimester lipid profile evaluation were included. In the multivariate analysis, pre-pregnancy BMI (OR 1.19 (95% CI 1.03-1.38), p = 0.022) and hypertriglyceridemia (OR 7.60 (1.70-34.10), p = 0.008) were independently associated with LGA. Third-trimester hypertriglyceridemia was found to be a predictor of LGA among women with GDM, independently of glycemic control, BMI, and pregnancy weight gain. Further investigation is needed to confirm the role of TGs in excessive fetal growth in GDM pregnancies.

Keywords: gestational diabetes; large for gestational age; lipid profile; maternal–fetal outcomes; triglycerides.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Clinical characteristics of pregnant women with GDM and their offspring.
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