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Review
. 2024 May 29;16(11):1665.
doi: 10.3390/nu16111665.

Influence of Metabolic Dysregulation in the Management of Depressive Disorder-Narrative Review

Paulina Jakubowska  1 , Marta Balcerczyk-Lis  1 , Milena Fortuna  1 , Aleksandra Janiak  1 , Adrianna Kopaczyńska  1 , Sylwia Skwira  1 , Ewelina Młynarska  1 , Jacek Rysz  2 , Beata Franczyk  1
Affiliations
Review

Influence of Metabolic Dysregulation in the Management of Depressive Disorder-Narrative Review

Paulina Jakubowska et al. Nutrients. .

Abstract

Depressive disorders are heterogeneous in nature, and their global reach makes them the cause of suffering for a million individuals worldwide. Standard treatment does not work for one in three people, and side effects can significantly reduce the quality of life. A multidisciplinary approach allows for a broader insight into the nature of the disease, given its complex etiology. One of its elements is the hypothesis of inflammation, which also accompanies obesity-related disease. Obesity and depression interact, causing many researchers to develop new non-pharmacological treatment methods for both diseases. One suggestion is physical exercises that have great potential to be used in clinical practice. They can exert changes on the central nervous system and thus modulate mood. Another is diet, which concentrates on active molecules that also affect the central nervous system (CNS). There is an urgent need to create appropriate criteria and recommendations that systematize existing knowledge and allow it to be used in practice. There is an urgent need to create appropriate criteria and recommendations that systematize existing knowledge and allow it to be used in practice.

Keywords: depression; inflammation; obesity.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The glut-brain axis. The above pathways mediate bidirectional communication between the brain and the gut microbiota. GI: gastrointestinal tract, HPA: hypothalamic-pituitary-adrenal axis, SCFAs: short-chain fatty acids, LPS: lipopolysaccharide, IL: interleukin, TNF: tumor necrosis factor, IFN: interferon.
Figure 2
Figure 2
MedDiet’s nutrition rules [78].
Figure 3
Figure 3
Odds ratio for the association between the occurrence of symptoms on the 10-item depression scale in the group of women using MedDiet and for comparison in the group of women with a high sugar and fat diet [86].
See this image and copyright information in PMC

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