Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 22;13(11):3040.
doi: 10.3390/jcm13113040.

Potential of Titanium Pins Coated with Fibroblast Growth Factor-2-Calcium Phosphate Composite Layers to Reduce the Risk of Impaired Bone-Pin Interface Strength in the External Fixation of Distal Radius Fractures

Hirotaka Mutsuzaki  1   2 , Yohei Yanagisawa  3 , Hiroshi Noguchi  4 , Atsuo Ito  5 , Masashi Yamazaki  4
Affiliations

Potential of Titanium Pins Coated with Fibroblast Growth Factor-2-Calcium Phosphate Composite Layers to Reduce the Risk of Impaired Bone-Pin Interface Strength in the External Fixation of Distal Radius Fractures

Hirotaka Mutsuzaki et al. J Clin Med. .

Abstract

Background: The risk of impaired bone-pin interface strength in titanium (Ti) pins coated with fibroblast growth factor (FGF)-calcium phosphate (CP) composite layers is yet to be evaluated in a clinical study. This retrospective study used Weibull plot analysis to evaluate bone-pin interface strength in Ti pins coated with FGF-CP layers for external distal radius fracture fixation. Methods: The distal radial fractures were treated with external fixation. The FGF-CP group comprised five patients (all women, aged 70.4 ± 5.9 (range: 62-77) years), and the uncoated pin group comprised ten patients (eight women and two men, aged 64.4 ± 11.7 (range: 43-83) years). The pins were removed after six weeks. The insertion and extraction peak torques were measured. The extraction peak torque was evaluated using Weibull plot analysis. Results: We compared the extraction torque of the two groups at or below 506 Nmm for a fair comparison using Weibull plot analysis. The Weibull plots were linear for both the FGF-CP and uncoated pin groups. The slope of the regression line was significantly higher in the FGF-CP group (1.7343) than in the uncoated pin group (1.5670) (p = 0.011). The intercept of the regression line was significantly lower in the FGF-CP group (-9.847) than in the uncoated pin group (-8.708) (p = 0.002). Thus, the two regression lines significantly differed. Conclusions: Ti pins coated with FGF-CP layers exhibit the potential to reduce the risk of impaired bone-pin interface strength in the external fixation of distal radius fractures.

Keywords: Weibull plot analysis; calcium phosphate; coating; distal radius fractures; external fixation; fibroblast growth factor-2 (FGF-2); impaired bone fixation.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
FGF-CP-coated pins.
Figure 2
Figure 2
External fixation for fractures of the distal radius. Immediately after surgery (left) and extraction peak torque measurement (right).
Figure 3
Figure 3
Relationship between the insertion and extraction torques. FGF-CP (left) and uncoated (right) pin groups.
Figure 4
Figure 4
The Weibull plot of extraction torque for the FGF-CP (left) and uncoated pin (right) groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Galbusera F., Volkheimer D., Reitmaier S., Berger-Roscher N., Kienle A., Wilke H.J. Pedicle screw loosening: A clinically relevant complication? Eur. Spine J. 2015;24:1005–1016. doi: 10.1007/s00586-015-3768-6. - DOI - PubMed
    1. Wu J.C., Huang W.C., Tsai H.W., Ko C.C., Wu C.L., Tu T.H., Cheng H. Pedicle screw loosening in dynamic stabilization: Incidence, risk, and outcome in 126 patients. Neurosurg. Focus. 2011;31:E9. doi: 10.3171/2011.7.FOCUS11125. - DOI - PubMed
    1. Kocak T., Cakir B., Reichel H., Mattes T. Screw loosening after posterior dynamic stabilization–review of the literature. Acta Chir. Orthop. Traumatol. Cech. 2010;77:134–139. doi: 10.55095/achot2010/025. - DOI - PubMed
    1. Moroni A., Cadossi M., Romagnoli M., Faldini C., Giannini S. A biomechanical and histological analysis of standard versus hydroxyApatite-coated pins for external fixation. J. Biomed. Mater. Res. B Appl. Biomater. 2008;86:417–421. doi: 10.1002/jbm.b.31036. - DOI - PubMed
    1. Moroni A., Pegreffi F., Cadossi M., Hoang-Kim A., Lio V., Giannini S. Hydroxyapatite-coated external fixation pins. Expert Rev. Med. Devices. 2005;2:465–471. doi: 10.1586/17434440.2.4.465. - DOI - PubMed

LinkOut - more resources