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Review
. 2024 May 31;13(11):3254.
doi: 10.3390/jcm13113254.

Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases

Barbara Pala  1 , Laura Pennazzi  2 , Giulia Nardoianni  1 , Federica Fogacci  3 , Arrigo F G Cicero  3   4 , Laura Di Renzo  5   6 , Emanuele Barbato  1 , Giuliano Tocci  1
Affiliations
Review

Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases

Barbara Pala et al. J Clin Med. .

Abstract

Background: Over the past decade, the gut microbiome (GM) has progressively demonstrated to have a central role in human metabolism, immunity, and cardiometabolic risk. Likewise, sleep disorders showed an impact on individual health and cardiometabolic risk. Recent studies seem to suggest multi-directional relations among GM, diet, sleep, and cardiometabolic risk, though specific interactions are not fully elucidated. We conducted a systematic review to synthesize the currently available evidence on the potential interactions between sleep and GM and their possible implications on cardiometabolic risk. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analyses, including articles from January 2016 until November 2022. Narrative syntheses were employed to describe the results. Results: A total of 8 studies were selected according to these criteria. Our findings indicated that the sleep disorder and/or the acute circadian rhythm disturbance caused by sleep-wake shifts affected the human GM, mainly throughout microbial functionality. Conclusions: Sleep disorders should be viewed as cardiovascular risk factors and targeted for preventive intervention. More research and well-designed studies are needed to completely assess the role of sleep deprivation in the multi-directional relationship between GM and cardiometabolic risk.

Keywords: PRISMA; cardiometabolic risk; cardiovascular risk; gut microbiome; sleep disorders; systematic review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram systematic reviews.
See this image and copyright information in PMC

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