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Review
. 2024 Jun 4;13(11):3321.
doi: 10.3390/jcm13113321.

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients-A Comprehensive Review

Sara Gómez-Melero  1 , Javier Caballero-Villarraso  1   2   3 , Begoña Mª Escribano  1   4 , Alejandro Galvao-Carmona  1   5 , Isaac Túnez  1   3 , Eduardo Agüera-Morales  1   6
Affiliations
Review

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients-A Comprehensive Review

Sara Gómez-Melero et al. J Clin Med. .

Abstract

Multiple sclerosis (MS) is characterized by a variety of symptoms that have a major impact on quality of life (QoL) even in early stages. In addition to individual motor, sensory, visual disturbances, and brainstem and sphincter disorders, which are expressed through the widely used Expanded Disability Status Scale (EDSS), other manifestations of MS have a detrimental effect on overall functioning and quality of life, such as cognitive impairment, depression, anxiety, fatigue, and pain. However, when talking about QoL, categorical definitions cannot be used because although the concept is generally understood, it is highly nuanced. Suffering from MS can significantly reduce QoL. Numerous research studies have focused on trying to identify and assess which are the elements that most affect the loss of QoL in MS people. However, in addition to the fact that the measurement of QoL can be subjective, it is very difficult to consider these elements in isolation, as they are interrelated. One such limiting factor of QoL that has been investigated is cognitive impairment (CI). This has been shown to have an impact on the lives of MS people, although the different approaches that have been taken to assess CI have evident limitations.

Keywords: cognitive impairment; disability; multiple sclerosis; neurodegenerative diseases; quality of life.

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Conflict of interest statement

This study has no sponsors or incentives, nor did it require funding for its development. Neither the participating investigators nor the hospital center have received any financial compensation. The authors declare that they have no conflicts of interest.

References

    1. Jakimovski D., Bittner S., Zivadinov R., Morrow S.A., Benedict R.H., Zipp F., Weinstock-Guttman B. Multiple sclerosis. Lancet. 2024;403:183–202. doi: 10.1016/S0140-6736(23)01473-3. - DOI - PubMed
    1. Walton C., King R., Rechtman L., Kaye W., Leray E., Marrie R.A., Robertson N., La Rocca N., Uitdehaag B., Van Der Mei I., et al. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult. Scler. 2020;26:1816–1821. doi: 10.1177/1352458520970841. - DOI - PMC - PubMed
    1. Logroscino G., Piccininni M., Marin B., Nichols E., Abd-Allah F., Abdelalim A., Alahdab F., Asgedom S.W., Awasthi A., Chaiah Y., et al. Global, regional, and national burden of motor neuron diseases 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018;17:1083–1097. doi: 10.1016/S1474-4422(18)30404-6. - DOI - PMC - PubMed
    1. Koch-Henriksen N., Magyari M. Apparent changes in the epidemiology and severity of multiple sclerosis. Nat. Rev. Neurol. 2021;17:676–688. doi: 10.1038/S41582-021-00556-Y. - DOI - PubMed
    1. Ghasemi N., Razavi S., Nikzad E. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses andCell-Based Therapy. Cell J. 2017;19:1. doi: 10.22074/CELLJ.2016.4867. - DOI - PMC - PubMed

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