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. 2024 May 21;16(11):1952.
doi: 10.3390/cancers16111952.

Internal Responsiveness of EQ-5D-5L and EORTC QLQ-C30 in Dutch Breast Cancer Patients during the First Year Post-Surgery: A Longitudinal Cohort Study

Noëlle J M C Vrancken Peeters  1   2 , Janine A van Til  3 , Anouk S Huberts  4 , Sabine Siesling  3   5 , Olga Husson  1   2 , Linetta B Koppert  1   4
Affiliations

Internal Responsiveness of EQ-5D-5L and EORTC QLQ-C30 in Dutch Breast Cancer Patients during the First Year Post-Surgery: A Longitudinal Cohort Study

Noëlle J M C Vrancken Peeters et al. Cancers (Basel). .

Abstract

The EuroQoL 5-Dimension 5-Level questionnaire (EQ-5D-5L) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) are commonly used Patient-Reported Outcome Measures (PROMs) for breast cancer. This study assesses and compares the internal responsiveness of the EQ-5D-5L and EORTC QLQ-C30 in Dutch breast cancer patients during the first year post-surgery. Women diagnosed with breast cancer who completed the EQ-5D-5L and EORTC QLQ-C30 pre-operatively (T0), 6 months (T6), and 12 months post-surgery (T12) were included. Mean differences of the EQ-5D-5L and EORTC QLQ-C30 between baseline and 6 months (delta 1) and between baseline and 12 months post-surgery (delta 2) were calculated and compared against the respective minimal clinically important differences (MCIDs) of 0.08 and 5. Internal responsiveness was assessed using effect sizes (ES) and standardized response means (SRM) for both deltas. In total, 333 breast cancer patients were included. Delta 1 and delta 2 for the EQ-5D-5L index and most scales of the EORTC QLQ-C30 were below the MCID. The internal responsiveness for both PROMs was small (ES and SRM < 0.5), with greater internal responsiveness for delta 1 compared to delta 2. The EQ-5D-5L index showed greater internal responsiveness than the EORTC QLQ-C30 Global Quality of Life scale and summary score. These findings are valuable for the interpretation of both PROMs in Dutch breast cancer research and clinical care.

Keywords: Breast Cancer; EuroQoL 5-Dimension 5-Level questionnaire (EQ-5D-5L); European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30); Patient-Reported Outcome Measures (PROMs); Responsiveness.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart. T0, baseline; T6, 6 months post-surgery; T12, 12 months post-surgery.
Figure 2
Figure 2
Boxplots of delta 1 (a) and delta 2 (b) for the EQ-5D-5L index (red) and of delta 1 (c) and delta 2 (d) for the EORTC QLQ-C30 Global health status (blue). The horizontal line in each boxplot represents the median value, while the white dot indicates the mean. The number within the boxplot represents the mean delta value. The grey interval represents the MCID of the EQ-5D-5L (0.08) and of the EORTC QLQ-C30 (5).
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