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. 2024 May 22;29(11):2439.
doi: 10.3390/molecules29112439.

Non-Enzymatic Glucose Sensors Composed of Polyaniline Nanofibers with High Electrochemical Performance

Nebras Sobahi  1 , Md Mottahir Alam  1 , Mohd Imran  2 , Mohammad Ehtisham Khan  3 , Akbar Mohammad  4 , Taeho Yoon  4 , Ibrahim M Mehedi  1   5 , Mohammad A Hussain  1 , Mohammed J Abdulaal  1 , Ahmad A Jiman  1
Affiliations

Non-Enzymatic Glucose Sensors Composed of Polyaniline Nanofibers with High Electrochemical Performance

Nebras Sobahi et al. Molecules. .

Abstract

The measurement of glucose concentration is a fundamental daily care for diabetes patients, and therefore, its detection with accuracy is of prime importance in the field of health care. In this study, the fabrication of an electrochemical sensor for glucose sensing was successfully designed. The electrode material was fabricated using polyaniline and systematically characterized using scanning electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and UV-visible spectroscopy. The polyaniline nanofiber-modified electrode showed excellent detection ability for glucose with a linear range of 10 μM to 1 mM and a detection limit of 10.6 μM. The stability of the same electrode was tested for 7 days. The electrode shows high sensitivity for glucose detection in the presence of interferences. The polyaniline-modified electrode does not affect the presence of interferences and has a low detection limit. It is also cost-effective and does not require complex sample preparation steps. This makes it a potential tool for glucose detection in pharmacy and medical diagnostics.

Keywords: electrochemical detection; fiber; glucose; polyaniline; sensing.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Field emission scanning electron microscope and (b) high-resolution transmission electron microscope image of polyaniline nanofibers.
Figure 2
Figure 2
(a) XRD diffractogram, (b) FTIR spectrum, and (c) Raman spectrum of polyaniline.
Figure 3
Figure 3
(a) Absorbance spectrum and (b) Tauc’s plot of polyaniline.
Figure 4
Figure 4
The schematic for the electrochemical mechanism for sensing glucose.
Figure 5
Figure 5
(a) Cyclic voltammetry, (b) Nyquist plot of bare, modified electrode and in the presence of glucose, (c) cyclic voltammetry at different scan rates, and (d) plot between the current and square root of scan rate.
Figure 6
Figure 6
(a) CV and (c) EIS plot of glucose at different concentrations. Calibration curve with the linear equation plotted for (b) CV and (d) EIS.
Figure 7
Figure 7
(a) Selectivity of the electrode in the presence of interference and (b) the stability of the same electrode for 7 days.
Figure 8
Figure 8
The schematic for the synthesis of polyaniline by polymerization method.
See this image and copyright information in PMC

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