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. 2024 May 30;29(11):2576.
doi: 10.3390/molecules29112576.

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Filipa Baptista  1 , Jessica Paié-Ribeiro  2 , Mariana Almeida  2 , Ana Novo Barros  1
Affiliations

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Filipa Baptista et al. Molecules. .

Abstract

Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.

Keywords: chronic liver diseases; diabetes; herbal medicine; nephrotoxicity; renal injury.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Chronic kidney disease-related conditions.
Figure 2
Figure 2
PRISMA 2020 flow diagram for new systematic reviews which included searches of databases and registers only.
Figure 3
Figure 3
Oxidative stress: Nrf2 signaling pathway (adapted from Hammad et al. [56]).
See this image and copyright information in PMC

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