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. 2024 May 26;14(11):1105.
doi: 10.3390/diagnostics14111105.

Hypertriglyceridemia-Induced Acute Pancreatitis-The Milky Way Constellation-The Seven-Year Experience of a Large Tertiary Centre

Andrei Vicențiu Edu  1   2 , Mihai Radu Pahomeanu  1   2   3 , Andreea Irina Ghiță  1   3 , Dalia Ioana Constantinescu  1   3 , Daniela Gabriela Grigore  1   3 , Andreea Daniela Bota  1   4 , Daniela Maria Luta-Dumitrașcu  4 , Cristian George Țieranu  1   4 , Lucian Negreanu  1   2   3
Affiliations

Hypertriglyceridemia-Induced Acute Pancreatitis-The Milky Way Constellation-The Seven-Year Experience of a Large Tertiary Centre

Andrei Vicențiu Edu et al. Diagnostics (Basel). .

Abstract

(1) Background: Hypertriglyceridemia (HTG) is a well-known metabolic condition associated with an increased risk of acute pancreatitis. In this study, we tried to establish whether there are any significant disparities concerning recurrence rate, intensive care unit (ICU) admission, hospital (ICU and total) length of stay (LoS), morphology, severity and age between HTG-induced acute pancreatitis and any other known cause of pancreatitis (OAP). (2) Methods: The research was a retrospective unicentric cohort study, using information from the Bucharest Acute Pancreatitis Index (BUC-API) registry, a database of 1855 consecutive cases of acute pancreatitis. (3) Results: We found a weak association between HTG-AP and recurrence. The HTG-AP patients were younger, with a median of 44.5 years, and had a longer ICU stay than the OAP patients. In addition, we identified that the HTG-AP patients were more likely to develop acute peripancreatic fluid collection (APFC), to be admitted in ICU, to have a more severe course of disease and to be cared for in a gastroenterology ward. (4) Conclusions: Hypertriglyceridemia-induced APs have a more severe course. The typical patient with HTG-AP is a middle-aged male, with previous episodes of AP, admitted in the gastroenterology ward, with a longer ICU stay and longer length of hospitalization, more likely to evolve in a severe acute pancreatitis (SAP) and with a higher probability of developing APFC.

Keywords: ICU; acute pancreatitis; hypertriglyceridemia; outcome; recurrence; severity.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
The milky serum of a patient with dyslipidaemia as photographed by J. Hecht in the 1960s (courtesy of the National Library of Medicine).
See this image and copyright information in PMC

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