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Review
. 2024 May 28;14(11):1119.
doi: 10.3390/diagnostics14111119.

Pulmonary Hypertension and Hyperglycemia-Not a Sweet Combination

Or Bruck  1 , L M Pandit  1   2
Affiliations
Review

Pulmonary Hypertension and Hyperglycemia-Not a Sweet Combination

Or Bruck et al. Diagnostics (Basel). .

Abstract

Hyperglycemia and pulmonary hypertension (PH) share common pathological pathways that lead to vascular dysfunction and resultant cardiovascular complications. These shared pathologic pathways involve endothelial dysfunction, inflammation, oxidative stress, and hormonal imbalances. Individuals with hyperglycemia or pulmonary hypertension also possess shared clinical factors that contribute to increased morbidity from both diseases. This review aims to explore the relationship between PH and hyperglycemia, highlighting the mechanisms underlying their association and discussing the clinical implications. Understanding these common pathologic and clinical factors will enable early detection for those at-risk for complications from both diseases, paving the way for improved research and targeted therapeutics.

Keywords: endothelial dysfunction; vascular inflammation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Interplay between Hyperglycemia, Insulin Resistance and Pulmonary Hypertension (PH). HIV—human immunodeficiency virus; HFpEF—heart failure with preserved ejection fraction; HFrEF—heart failure with reduced ejection fraction; COPD—chronic obstructive pulmonary disease; VTE—venous thromboembolic disease.
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