Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 May 28;14(11):1119.
doi: 10.3390/diagnostics14111119.

Pulmonary Hypertension and Hyperglycemia-Not a Sweet Combination

Or Bruck  1 , L M Pandit  1   2
Affiliations
Review

Pulmonary Hypertension and Hyperglycemia-Not a Sweet Combination

Or Bruck et al. Diagnostics (Basel). .

Abstract

Hyperglycemia and pulmonary hypertension (PH) share common pathological pathways that lead to vascular dysfunction and resultant cardiovascular complications. These shared pathologic pathways involve endothelial dysfunction, inflammation, oxidative stress, and hormonal imbalances. Individuals with hyperglycemia or pulmonary hypertension also possess shared clinical factors that contribute to increased morbidity from both diseases. This review aims to explore the relationship between PH and hyperglycemia, highlighting the mechanisms underlying their association and discussing the clinical implications. Understanding these common pathologic and clinical factors will enable early detection for those at-risk for complications from both diseases, paving the way for improved research and targeted therapeutics.

Keywords: endothelial dysfunction; vascular inflammation.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Interplay between Hyperglycemia, Insulin Resistance and Pulmonary Hypertension (PH). HIV—human immunodeficiency virus; HFpEF—heart failure with preserved ejection fraction; HFrEF—heart failure with reduced ejection fraction; COPD—chronic obstructive pulmonary disease; VTE—venous thromboembolic disease.
See this image and copyright information in PMC

References

    1. Humbert M., Guignabert C., Bonnet S., Dorfmüller P., Klinger J.R., Nicolls M.R., Olschewski A.J., Pullamsetti S.S., Schermuly R.T., Stenmark K.R., et al. Pathology and pathobiology of pulmonary hypertension: State of the art and research perspectives. Eur. Respir. J. 2019;53:1801887. doi: 10.1183/13993003.01887-2018. - DOI - PMC - PubMed
    1. Simonneau G., Montani D., Celermajer D.S., Denton C.P., Gatzoulis M.A., Krowka M., Williams P.G., Souza R. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur. Respir. J. 2019;53:1801913. doi: 10.1183/13993003.01913-2018. - DOI - PMC - PubMed
    1. Humbert M., Kovacs G., Hoeper M.M., Badagliacca R., Berger R.M., Brida M., Carlsen J., Coats A.J., Escribano-Subias P., Ferrari P., et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur. Respir. J. 2023;61:2200879. doi: 10.1183/13993003.00879-2022. - DOI - PubMed
    1. Xu W., Janocha A.J., Erzurum S.C. Metabolism in Pulmonary Hypertension. Annu. Rev. Physiol. 2021;83:551–576. doi: 10.1146/annurev-physiol-031620-123956. - DOI - PMC - PubMed
    1. Xu W., Erzurum S.C. Endothelial cell energy metabolism, proliferation, and apoptosis in pulmonary hypertension. Compr. Physiol. 2011;1:357–372. doi: 10.1002/cphy.c090005. - DOI - PMC - PubMed

LinkOut - more resources