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. 2024 May 29;14(11):1136.
doi: 10.3390/diagnostics14111136.

Trajectory of Diastolic Function after Heart Transplantation as Assessed by Left Atrial Deformation Analysis

Borbála Edvi  1 , Alexandra Assabiny  1 , Tímea Teszák  1 , Máté Tolvaj  1 , Alexandra Fábián  1 , István Hartyánszky  1 , Miklós Pólos  1 , Bálint Károly Lakatos  1 , Hajnalka Vágó  1 , Balázs Sax  1 , Béla Merkely  1 , Attila Kovács  1   2
Affiliations

Trajectory of Diastolic Function after Heart Transplantation as Assessed by Left Atrial Deformation Analysis

Borbála Edvi et al. Diagnostics (Basel). .

Abstract

Diastolic dysfunction (DD) is a prevalent and clinically significant complication after heart transplantation (HTX). We aimed to characterize the diastolic function of HTX recipients with both short-term and long-term follow-ups by applying left atrial (LA) deformation analysis. We consecutively enrolled and followed up with 33 HTX patients. Three assessments were performed one month, 3-5 months, and 3-5 years after surgery. Beyond conventional echocardiographic measurements, apical four-chamber views optimized for speckle tracking analysis were acquired and post-processed by dedicated software solutions (TomTec AutoStrain LA and LV). Left atrial phasic functions were characterized by reservoir, conduit, and contraction strains. We categorized diastolic function according to current guidelines (normal diastolic function, indeterminate, DD). At the first assessment, nine (27%) patients were in the DD category, and eleven (33%) were indeterminate. At the second assessment, only one patient (3%) remained in the DD category and six (18%) were indeterminate. At the third assessment, 100% of patients were categorized as having normal diastolic function. LA reservoir strain gradually increased over time. LA contraction strain significantly improved from the second to the third assessment. We found a correlation between the LA reservoir strain and NT-proBNP (r = 0.40, p < 0.05). DD is prevalent immediately after HTX but rare until the end of the first postoperative quarter. Speckle tracking analysis enables the characterization of LA phasic functions that may reflect both short- and long-term changes in diastolic function and correlate with NT-proBNP.

Keywords: diastolic function; heart failure; heart transplantation; left atrium; longitudinal strain.

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Conflict of interest statement

A.K. serves as Chief Medical Officer of Argus Cognitive, Inc. (Budapest, Hungary), and receives financial compensation for his work outside the current project. No other authors report competing interests directly or indirectly related to the work submitted for publication.

Figures

Figure 1
Figure 1
Distribution of diastolic function categories according to current echocardiographic guidelines at the three assessments after heart transplantation.
Figure 2
Figure 2
Sankey diagram to visualize reclassification from normal diastolic function (No DD), intermediate, and diastolic dysfunction (DD) over the three assessments (V1, V2, and V3).
Figure 3
Figure 3
Left atrial deformation analysis of a representative patient—screenshots from the dedicated software’s user interface. (Left) panels: apical four-chamber view images with the overlaid region of interest. (Right) panels: volume–longitudinal strain curves with reservoir (LASr) and contraction (LASct) strains highlighted. The reservoir strain gradually increases over time. The contraction strain significantly improves from the second to third assessment.
See this image and copyright information in PMC

References

    1. Tallaj J.A., Kirklin J.K., Brown R.N., Rayburn B.K., Bourge R.C., Benza R.L., Pinderski L., Pamboukian S., McGiffin D.C., Naftel D.C. Post-heart transplant diastolic dysfunction is a risk factor for mortality. J. Am. Coll. Cardiol. 2007;50:1064–1069. doi: 10.1016/j.jacc.2007.06.007. - DOI - PubMed
    1. Sciaccaluga C., Fusi C., Landra F., Barilli M., Lisi M., Mandoli G.E., D’ascenzi F., Focardi M., Valente S., Cameli M. Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis. Front. Cardiovasc. Med. 2022;9:969270. doi: 10.3389/fcvm.2022.969270. - DOI - PMC - PubMed
    1. Nagueh S.F., Smiseth O.A., Appleton C.P., Byrd B.F., 3rd, Dokainish H., Edvardsen T., Flachskampf F.A., Gillebert T.C., Klein A.L., Lancellotti P., et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2016;29:277–314. doi: 10.1016/j.echo.2016.01.011. - DOI - PubMed
    1. Zhubi Bakija F., Bagyura Z., Fábián A., Ferencz A., Kiss L., Szenczi O., Vadas R., Dósa E., Nguyen D.T., Csobay-Novák C., et al. Long-term prognostic value of left atrial longitudinal strain in an elderly community-based cohort. Geroscience. 2023;45:613–625. doi: 10.1007/s11357-022-00673-6. - DOI - PMC - PubMed
    1. Lang R.M., Badano L.P., Mor-Avi V., Afilalo J., Armstrong A., Ernande L., Flachskampf F.A., Foster E., Goldstein S.A., Kuznetsova T., et al. Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2015;28:1–39.e14. doi: 10.1016/j.echo.2014.10.003. - DOI - PubMed