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. 2024 Jun 5;14(11):1185.
doi: 10.3390/diagnostics14111185.

Live-Birth Incidence of Isolated D-Transposition of Great Arteries-The Shift in Trends Due to Early Diagnosis

Andreea Florentina Stancioi-Cismaru  1   2 , Marina Dinu  3 , Andreea Carp-Veliscu  4   5 , Razvan Grigoras Capitanescu  3   6 , Razvan Cosmin Pana  6 , Ovidiu Costinel Sirbu  3   6 , Florentina Tanase  6 , Florentina Gratiela Dita  2   6 , Maria Adelina Popa  6 , Mihai Robert Robu  6 , Mihaela Gheonea  3   6 , Stefania Tudorache  3   6
Affiliations

Live-Birth Incidence of Isolated D-Transposition of Great Arteries-The Shift in Trends Due to Early Diagnosis

Andreea Florentina Stancioi-Cismaru et al. Diagnostics (Basel). .

Abstract

This is a single tertiary population-based study conducted at a center in southwest Romania. We retrospectively compared data obtained in two periods: January 2008-December 2013 and January 2018-December 2023. The global incidence of the transposition of great arteries in terminated cases, in addition to those resulting in live-born pregnancies, remained almost constant. The live-birth incidence decreased. The median gestational age at diagnosis decreased from 29.3 gestational weeks (mean 25.4) to 13.4 weeks (mean 17.2). The second trimester and the overall detection rate in the prenatal period did not significantly change, but the increase was statistically significant in the first trimester. The proportion of terminated pregnancies in fetuses diagnosed with the transposition of great arteries significantly increased (14.28% to 75%, p = 0.019).

Keywords: counseling; live-birth incidence; prenatal diagnosis; termination of pregnancy; transposition of great arteries; ultrasound.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Details at the FT cardiac sweep in a normal (a,b) and in a TGA case (c).
Figure 2
Figure 2
TGA cases: right ventricle outflow tract (RVOT) at level of the three-vessel and trachea (3VT) view (a) and parallel arterial trunks (b).
Figure 3
Figure 3
Flowchart presenting the selected study population and the number of cases in both cohorts. Abbreviations: Dx = diagnosis; FT = first trimester, ST = second trimester, TT = third trimester; TOP = termination of pregnancy.
Figure 4
Figure 4
Graphical representation of gestational age at diagnosis (blue dots—the historical cohort, pink dots—the recent cohort; trends are represented by dotted lines).
Figure 5
Figure 5
Postabortum conventional autopsy details: (a) Specimen after first-trimester medical TOP; CRL (crown–rump length) 68 mm. In upper window, fetal heart is shown in transverse section on operator’s fingers; comparative size can be seen. (b) Specimen after second-trimester medical TOP; an accurate diagnosis of TGA is reachable.
See this image and copyright information in PMC

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