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. 2024 Jun 4:15:1374376.
doi: 10.3389/fendo.2024.1374376. eCollection 2024.

Association between monocyte to high-density lipoprotein cholesterol ratio and kidney stone: insights from NHANES

Zhaoxiang Wang #  1 , Guang Zhao #  2 , Yuanfei Cao #  3 , Tian Gu  4   5 , Qichao Yang  4   5
Affiliations

Association between monocyte to high-density lipoprotein cholesterol ratio and kidney stone: insights from NHANES

Zhaoxiang Wang et al. Front Endocrinol (Lausanne). .

Abstract

Purpose: The ratio of monocyte to high-density lipoprotein cholesterol (MHR) has surfaced as a novel biomarker indicative of inflammation and oxidative stress. The aim of our study was to evaluate the association between MHR and the risk of kidney stones.

Methods: This study analyzed data from individuals aged 20-79 who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018. The MHR was assessed as the exposure variable, while a self-reported history of kidney stones was used as the outcome variable. The independent relationship between MHR and the risk of kidney stones was thoroughly evaluated.

Results: This study included 28,878 participants, and as the quartile range of the MHR increased, the proportion of kidney stones also rose progressively (7.20% to 8.89% to 10.88% to 12.05%, P<0.001). After adjusting for confounding factors, MHR was independently associated with an increased risk of kidney stones (OR=1.31, 95%CI=1.11-1.54, P=0.001), also independent of some common inflammatory indices. Subgroup analysis suggested that the relationship between MHR and kidney stones was more pronounced in female and individuals aged 20-49. Further restricted cubic spline (RCS) analysis indicated a nonlinear relationship between MHR and the risk of kidney stones.

Conclusion: Our results indicate a positive correlation between MHR and an increased risk of kidney stones in US adults, underscoring the need for further large-scale prospective cohort studies to validate these findings.

Keywords: NHANES; inflammation; kidney stone; monocyte to high-density lipoprotein cholesterol ratio; oxidative stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
DCA results.
Figure 2
Figure 2
The results of subgroup analyses. (Age, gender, and race, annual household income, education level, smokers, hypertension, diabetes, cardiovascular disease, BMI, ALT, AST, GGT, glycohemoglobin, TG, BUN, Scr, and SUA were adjusted).
Figure 3
Figure 3
The results of RCS analysis. (Age, gender, and race, annual household income, education level, smokers, hypertension, diabetes, cardiovascular disease, BMI, ALT, AST, GGT, glycohemoglobin, TG, BUN, Scr, and SUA were adjusted).
See this image and copyright information in PMC

References

    1. Peerapen P, Thongboonkerd V. Kidney stone prevention. Adv Nutr. (2023) 14:555–69. doi: 10.1016/j.advnut.2023.03.002 - DOI - PMC - PubMed
    1. Coe FL, Evan A, Worcester E. Kidney stone disease. J Clin Invest. (2005) 115:2598–608. doi: 10.1172/jci26662 - DOI - PMC - PubMed
    1. Abufaraj M, Xu T, Cao C, Waldhoer T, Seitz C, D’Andrea D, et al. Prevalence and trends in kidney stone among adults in the USA: analyses of national health and nutrition examination survey 2007-2018 data. Eur Urol Focus. (2021) 7:1468–75. doi: 10.1016/j.euf.2020.08.011 - DOI - PubMed
    1. Scales CD, Jr., Smith AC, Hanley JM, Saigal CS. Prevalence of kidney stones in the United States. Eur Urol. (2012) 62:160–5. doi: 10.1016/j.eururo.2012.03.052 - DOI - PMC - PubMed
    1. Singh P, Harris PC, Sas DJ, Lieske JC. The genetics of kidney stone disease and nephrocalcinosis. Nat Rev Nephrol. (2022) 18:224–40. doi: 10.1038/s41581-021-00513-4 - DOI - PubMed