Novel Compounds as S1P5 Modulators for Treating Neurodegenerative Diseases
- PMID: 38894913
- PMCID: PMC11181510
- DOI: 10.1021/acsmedchemlett.4c00178
Novel Compounds as S1P5 Modulators for Treating Neurodegenerative Diseases
Abstract
Provided herein are novel compounds as S1P5 modulators, pharmaceutical compositions, use of such compounds in treating neurodegenerative diseases, particularly Alzheimer's disease, multiple sclerosis, migraine and amyotrophic lateral sclerosis, and processes for preparing such compounds.
Published 2024 by American Chemical Society.
Conflict of interest statement
The authors declare no competing financial interest.
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References
-
- Lebmann V.; Kartalou G.; Endres T.; Pawlitzki M.; Gottmann K. Repurposing drugs against Alzheimer’s disease: can the anti-multiple sclerosis drug fingolimod (FTY720) effectively tackle inflammation processes in AD?. J. Neural Transm. 2023, 130, 1003–1012. 10.1007/s00702-023-02618-5. - DOI - PMC - PubMed
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