Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 4:12:1395961.
doi: 10.3389/fped.2024.1395961. eCollection 2024.

Proteinuria and hematuria as early signs of renal involvement in juvenile idiopathic arthritis

Emanuela Del Giudice  1 , Alessia Marcellino  1 , Sara Hoxha  1 , Vanessa Martucci  1 , Mariateresa Sanseviero  1 , Silvia Bloise  1 , Sara Giovanna De Maria  1 , Maria Rita Leone  1 , Flavia Ventriglia  1 , Riccardo Lubrano  1
Affiliations

Proteinuria and hematuria as early signs of renal involvement in juvenile idiopathic arthritis

Emanuela Del Giudice et al. Front Pediatr. .

Abstract

Objectives: To evaluate glomerular and tubular renal functions and analyze blood pressure in a cohort of pediatric patients with juvenile idiopathic arthritis (JIA).

Methods: A total of 40 pediatric patients, 20 (50%) with JIA and 20 (50%) healthy control subjects, were studied, and performed the renal function on 24-h collection and the 24-h ambulatory blood pressure monitoring (ABPM). Moreover, we compared renal function and blood pressure trends between the groups of JIA patients with different disease activities.

Results: No statistically significant differences were observed between patients with JIA and healthy children in terms of glomerular filtration rate (GFR), fractional excretion of sodium (FENa), tubular reabsorption of phosphate (TRP), and calcium-creatinine urine ratio (CaU/CrU). In contrast, we observed significantly higher values in JIA patients than in controls for the presence of hematuria (p < 0.0001) and proteinuria (p < 0.0001). Compared to the control group there were significantly higher values of hematuria and proteinuria/day in both groups of JIA patients with low disease activity (respectively, p = 0.0001 and p = 0.0002) and moderate disease activity (respectively p = 0.0001 and p = 0.0012). Systolic and diastolic dipping were significantly reduced in patients with JIA compared with healthy controls (p < 0.0001 and p < 0.0001, respectively).

Conclusions: Our study showed that children with JIA, already in the early stages of the disease, have higher values of hematuria and proteinuria, which are early warning signs of nephropathy. Therefore, detailed screening of renal function and pressure monitoring in patients are necessary to monitor their evolution over time.

Keywords: blood pressure; glomerular function; hematuria; juvenile idiopathic arthritis; pediatric proteinuria; tubular renal function.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Proteinuria in JIA children with low and moderate disease activity compared to healthy controls.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet. (2007) 369(9563):767–78. 10.1016/S0140-6736(07)60363-8 - DOI - PubMed
    1. Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. (2004) 31(2):390–2. PMID: . - PubMed
    1. Del Giudice E, Simio C, Scala A, Di Coste A, La Torre G, Spadea L, et al. Juvenile idiopathic arthritis-associated uveitis in the era of biological therapy: how the disease changed in more than 20 years of observation in a tertiary referral center in Rome (Italy). Int Ophthalmol. (2022) 42(3):775–84. 10.1007/s10792-021-02043-1 - DOI - PMC - PubMed
    1. Del Giudice E, Swart JF, Wulffraat NM. Juvenile idiopathic arthritis. Com Rheum Dis. (2017) 5:265–88. 10.1007/978-3-319-59963-2_13 - DOI
    1. Casa FD, Vitale A, Guerriero S, Sota J, Cimaz R, Ragab G, et al. Development and implementation of the AIDA international registry for patients with non-infectious uveitis. Ophthalmol Ther. (2022) 11(2):899–911. 10.1007/s40123-022-00459-1 - DOI - PMC - PubMed

LinkOut - more resources