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Comparative Study
. 1985;199(1):152-3.
doi: 10.1007/BF00327525.

Replicating instabilities in yeast: occurrence in different mutational systems

A Nasim, E R Stephen, J A Erratt
Comparative Study

Replicating instabilities in yeast: occurrence in different mutational systems

A Nasim et al. Mol Gen Genet. 1985.

Abstract

Following mutagenesis of yeast cells with nitrosoguanidine, primary mosaic colonies exhibiting prototrophic/auxotrophic phenotypes were obtained. Upon replating of these primary mosaics, numerous secondary mosaics were present in the progeny. This study shows that replicating instabilities occur at many different loci within the Schizosaccharomyces pombe genome. In addition, the ade-1 gene of Saccharomyces cerevisiae (causing red pigmentation) was used to show that the phenomenon also occurs in this yeast.

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