Risk factors for prevalent and incident hypertension in rheumatoid arthritis: data from the Canadian Early Arthritis Cohort

Brook Hadwen¹, Saverio Stranges^{1

2

3

4}, Janet E Pope⁵, Susan Bartlett⁶, Gilles Boire⁷, Louis Bessette⁸, Carol A Hitchon⁹, Glen Hazlewood¹⁰, Edward C Keystone¹¹, Orit Schieir⁶, Carter Thorne¹², Diane Tin¹², Marie-France Valois⁶, Vivian Bykerk¹³, Lillian Barra^{1

3

5}; CATCH Investigators

Collaborators, Affiliations

Collaborators

CATCH Investigators:
Pooneh Akhavan, Louis Bessette, Gilles Boire, Vivian Bykerk, Ines Colmegna, Sabrina Fallavollita, Derek Haaland, Boulos Haraoui, Glen Hazlewood, Carol Hitchon, Shahin Jamal, Raman Joshi, Ed Keystone, Bindee Kuriya, Peter Panopalis, Janet Pope, Carter Thorne, Edith Villeneuve, Michel Zummer

Affiliations

¹ Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
² Department of Family Medicine, Western University, London, Ontario, Canada.
³ Lawson Health Research Institute, London, Ontario, Canada.
⁴ Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg.
⁵ Department of Medicine, Division of Rheumatology, Western University, London, Ontario, Canada.
⁶ Department of Medicine, Division of Rheumatology, McGill University, Montreal, Quebec, Canada.
⁷ Department of Medicine, Division of Rheumatology, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke and Université de Sherbrooke, Sherbrooke, Quebec, Canada.
⁸ Department of Medicine, Division of Rheumatology, Université Laval, Quebec, Quebec, Canada.
⁹ Department of Internal Medicine, Section of Rheumatology, University of Manitoba, Winnipeg, Manitoba, Canada.
¹⁰ Department of Medicine, Division of Rheumatology, University of Calgary, Calgary, Alberta, Canada.
¹¹ Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada.
¹² Centre of Arthritis Excellence, Newmarket, Ontario, Canada.
¹³ Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical, New York, NY, USA.

PMID: 38895593
PMCID: PMC11183658
DOI: 10.1093/rap/rkae066

Risk factors for prevalent and incident hypertension in rheumatoid arthritis: data from the Canadian Early Arthritis Cohort

Brook Hadwen et al. Rheumatol Adv Pract. 2024.

. 2024 May 22;8(2):rkae066.

doi: 10.1093/rap/rkae066. eCollection 2024.

Authors

Collaborators

CATCH Investigators:
Pooneh Akhavan, Louis Bessette, Gilles Boire, Vivian Bykerk, Ines Colmegna, Sabrina Fallavollita, Derek Haaland, Boulos Haraoui, Glen Hazlewood, Carol Hitchon, Shahin Jamal, Raman Joshi, Ed Keystone, Bindee Kuriya, Peter Panopalis, Janet Pope, Carter Thorne, Edith Villeneuve, Michel Zummer

Affiliations

¹ Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
² Department of Family Medicine, Western University, London, Ontario, Canada.
³ Lawson Health Research Institute, London, Ontario, Canada.
⁴ Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg.
⁵ Department of Medicine, Division of Rheumatology, Western University, London, Ontario, Canada.
⁶ Department of Medicine, Division of Rheumatology, McGill University, Montreal, Quebec, Canada.
⁷ Department of Medicine, Division of Rheumatology, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke and Université de Sherbrooke, Sherbrooke, Quebec, Canada.
⁸ Department of Medicine, Division of Rheumatology, Université Laval, Quebec, Quebec, Canada.
⁹ Department of Internal Medicine, Section of Rheumatology, University of Manitoba, Winnipeg, Manitoba, Canada.
¹⁰ Department of Medicine, Division of Rheumatology, University of Calgary, Calgary, Alberta, Canada.
¹¹ Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada.
¹² Centre of Arthritis Excellence, Newmarket, Ontario, Canada.
¹³ Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical, New York, NY, USA.

PMID: 38895593
PMCID: PMC11183658
DOI: 10.1093/rap/rkae066

Abstract

Objective: Hypertension (HTN) is a common comorbidity in RA. This study aimed to explore the prevalence and incidence of HTN and baseline factors associated with incident HTN in early RA (ERA).

Methods: Data were from the Canadian Early Arthritis Cohort (CATCH), an inception cohort of ERA patients having <1 year of disease duration. HTN was determined by patient- or physician-reported diagnosis, the use of anti-hypertensives and/or blood pressure. Multivariable logistic regression was performed to determine baseline factors associated with prevalent and incident HTN in this population.

Results: The study sample included 2052 ERA patients [mean age 55 years (s.d. 14), 71% female). The prevalence of HTN at study enrolment was 26% (23% in females and 34% in males). In both sexes, prevalent HTN was associated with older age, diabetes and hyperlipidaemia. HTN was associated with being overweight or high alcohol consumption in females. Of the RA patients who did not have HTN at enrolment, 24% (364/1518) developed HTN during the median follow-up period of 5 years (range 1-8). Baseline factors significantly associated with incident HTN were older age, being overweight, excess alcohol consumption and having hyperlipidaemia. Incident HTN was associated with high alcohol consumption in males and with hyperlipidaemia in females. RA-associated disease factors and treatments were not significantly associated with prevalent or incident HTN.

Conclusions: Early RA patients had a high incidence of hypertension with the highest risk in older patients with traditional cardiovascular risk factors.

Keywords: cardiovascular disease; cohort; comorbidities; hypertension; rheumatoid arthritis.

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References

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1. Hitchon CA, Boire G, Haraoui B. et al. Self-reported comorbidity is common in early inflammatory arthritis and associated with poorer function and worse arthritis disease outcomes: results from the Canadian Early Arthritis Cohort. Rheumatology (Oxford) 2016;55:1751–62. - PubMed
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Risk factors for prevalent and incident hypertension in rheumatoid arthritis: data from the Canadian Early Arthritis Cohort

Collaborators

Affiliations

Risk factors for prevalent and incident hypertension in rheumatoid arthritis: data from the Canadian Early Arthritis Cohort

Authors

Collaborators

Affiliations

Abstract

Figures

References

LinkOut - more resources

Full Text Sources