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Review
. 2024 Sep;29(5):883-907.
doi: 10.1007/s10741-024-10406-w. Epub 2024 Jun 19.

New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy

Weiteng Wang  1   2   3 , Hao Jia  1   2   3 , Xiumeng Hua  1   2   3 , Jiangping Song  4   5   6   7
Affiliations
Review

New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy

Weiteng Wang et al. Heart Fail Rev. 2024 Sep.

Abstract

Advances in the etiological classification of myocarditis and inflammatory cardiomyopathy (ICM) have reached a consensus. However, the mechanism of myocarditis/ICM remains unclear, which affects the development of treatment and the improvement of outcome. Cellular transcription and metabolic reprogramming, and the interactions between cardiomyocytes and non-cardiomyocytes, such as the immune cells, contribute to the process of myocarditis/ICM. Recent efforts have been made by multi-omics techniques, particularly in single-cell RNA sequencing, to gain a better understanding of the cellular landscape alteration occurring in disease during the progression. This article aims to provide a comprehensive overview of the latest studies in myocarditis/ICM, particularly as revealed by single-cell sequencing.

Keywords: Cardiomyocytes; Cellular landscape; Immune cell; Inflammatory cardiomyopathy; Myocarditis; Single-cell sequencing.

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References

    1. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO (2009) Sudden deaths in young competitive athletes: Analysis of 1866 deaths in the United States, 1980–2006. Circulation 119:1085–1092. https://doi.org/10.1161/circulationaha.108.804617 - DOI - PubMed
    1. Altman NL, Berning AA, Mann SC, Quaife RA, Gill EA, Auerbach SR, Campbell TB, Bristow MR (2023) Vaccination-associated myocarditis and myocardial injury. Circ Res 132:1338–1357. https://doi.org/10.1161/circresaha.122.321881 - DOI - PubMed - PMC
    1. Rroku A, Kottwitz J, Heidecker B (2020) Update on myocarditis - what we know so far and where we may be heading. Eur Heart J Acute Cardiovasc Care 10:455–467. https://doi.org/10.1177/2048872620910109 - DOI - PubMed
    1. Caforio AL, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Heliö T, Heymans S, Jahns R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss HP, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P, Elliott PM (2013) Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 34:2636–2648. https://doi.org/10.1093/eurheartj/eht210 - DOI - PubMed
    1. Trachtenberg BH, Hare JM (2017) Inflammatory cardiomyopathic syndromes. Circ Res 121:803–818. https://doi.org/10.1161/circresaha.117.310221 - DOI - PubMed

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