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. 2024 Jun 16;12(17):3045-3052.
doi: 10.12998/wjcc.v12.i17.3045.

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Yue Yin  1 , Yuan Yao  2 , Yi-Jie Li  2 , Li-Li Zhao  2 , Qiang Zhang  2
Affiliations

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Yue Yin et al. World J Clin Cases. .

Abstract

Background: Oral cancer, which is caused by mucous membrane variation, represents a prevalent malignant tumor in the oral and maxillofacial region, posing a significant threat to patients' lives and safety. While surgical intervention stands as a cornerstone treatment for oral cancer patients, it carries the risk of incomplete treatment or high rates of postoperative recurrence. Hence, a multifaceted approach incorporating diverse treatment modalities is essential to enhance patient prognosis.

Aim: To analyze the application effect of Tongluo Jiedu prescription as adjuvant therapy and its influence on patient prognosis in patients with oral cancer.

Methods: Eighty oral cancer patients in our hospital were selected and divided into the observation group and control group by a random number table. The control group was treated with continuous arterial infusion chemotherapy of cisplatin and 5-fluorouracil. The observation group was additionally given Tongluo Jiadu prescription. The inflammatory stress level, peripheral blood T-cell subsets, and immune function of the two groups were subsequently observed. SPSS 21.0 was used for data analysis.

Results: The observation group demonstrated lower levels of interleukin-6 and C-reactive protein, and a higher level of tumor necrosis factor in comparison to the control group. After treatment, the immune function in the observation group was significantly better than in the control group.

Conclusion: Tongluo Jiedu prescription can improve the immune function and oxidative stress level of patients with oral cancer and accelerate the recovery process.

Keywords: Immune function; Oral cancer patients; Oxidative stress; Tongluo Jiedu prescription.

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Conflict of interest statement

Conflict-of-interest statement: All authors declare no conflict of interest.

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