Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 May;82(10):3169-72.
doi: 10.1073/pnas.82.10.3169.

Amino acid sequence of a variant pro-form of insulin-like growth factor II

P P Zumstein, C Lüthi, R E Humbel

Amino acid sequence of a variant pro-form of insulin-like growth factor II

P P Zumstein et al. Proc Natl Acad Sci U S A. 1985 May.

Abstract

Human serum contains, in addition to the "classical" 7.5-kDa insulin-like growth factors (IGFs) I and II, small amounts of larger IGF-II. A 10-kDa IGF-II was isolated by gel filtration, immunoaffinity chromatography, and reversed-phase HPLC. Upon amino acid sequence determination, a substitution of Cys-Gly-Asp for Ser-33 was found as well as a COOH-terminal extension of 21 residues (E peptide). These sequence differences suggest that 10-kDa IGF-II is a precursor of a variant IGF-II. Since the substitution is not located at a known intron/exon hinge region, the finding of this variant IGF-II is evidence for the presence of more than one gene for IGF-II.

PubMed Disclaimer

References

    1. FEBS Lett. 1978 May 15;89(2):283-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Apr;82(7):2153-7 - PubMed
    1. Eur J Biochem. 1980 Jan;103(2):387-400 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3649-53 - PubMed
    1. Eur J Biochem. 1980 Oct;111(1):245-50 - PubMed

Publication types