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Review
. 2025 May;81(5):2419-2423.
doi: 10.1002/ps.8259. Epub 2024 Jun 20.

The discovery of indazapyroxamet: a novel 3-pyridinyl insecticide targeting piercing/sucking insectsa

Wenming Zhang  1 , Rachel D Slack  1 , Michael A Rossi  1 , Jason Hamm  1 , Daniel Cordova  1 , David Clark  1 , George Lahm  1 , Moumita Kar  1 , Kashinath Sana  1 , Ming Xu  1 , Andrew DeAngelis  1 , Breena Fraga  1
Affiliations
Review

The discovery of indazapyroxamet: a novel 3-pyridinyl insecticide targeting piercing/sucking insectsa

Wenming Zhang et al. Pest Manag Sci. 2025 May.

Abstract

In recent years, the registrations for a number of commercial insecticides utilized for piercing/sucking insects have been cancelled or restricted. To meet this growing need for new hemipteran controlling agrochemicals, we discovered a 2-(pyridin-3-yl)-thiazole compound, with limited insecticidal activity against cotton/melon aphid (Aphis gossypii). The 2-(pyridin-3-yl)-thiazole moiety offered us a basis to pursue the bicyclic 2-(pyridin-3-yl)-2H-indazole carboxamides. Evaluation of such 2-(pyridin-3-yl)-2H-indazole carboxamides revealed that even analogs containing only simple alkyl amides attached at the 4 or 5 positions possess promising insecticidal activity. Extensive optimization of this novel class of 2-(pyridin-3-yl)-2H-indazole carboxamides led to identifying indazapyroxamet for commercial development. © 2024 Society of Chemical Industry.

Keywords: 2‐(pyridin‐3‐yl)‐2H‐indazole; carboxamide; indazapyroxamet; insecticide; piercing/sucking.

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