Peritoneal dialysis versus haemodialysis for people commencing dialysis
- PMID: 38899545
- PMCID: PMC11187793
- DOI: 10.1002/14651858.CD013800.pub2
Peritoneal dialysis versus haemodialysis for people commencing dialysis
Abstract
Background: Peritoneal dialysis (PD) and haemodialysis (HD) are two possible modalities for people with kidney failure commencing dialysis. Only a few randomised controlled trials (RCTs) have evaluated PD versus HD. The benefits and harms of the two modalities remain uncertain. This review includes both RCTs and non-randomised studies of interventions (NRSIs).
Objectives: To evaluate the benefits and harms of PD, compared to HD, in people with kidney failure initiating dialysis.
Search methods: We searched the Cochrane Kidney and Transplant Register of Studies from 2000 to June 2024 using search terms relevant to this review. Studies in the Register were identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Registry Platform (ICTRP) Search Portal, and ClinicalTrials.gov. MEDLINE and EMBASE were searched for NRSIs from 2000 until 28 March 2023.
Selection criteria: RCTs and NRSIs evaluating PD compared to HD in people initiating dialysis were eligible.
Data collection and analysis: Two investigators independently assessed if the studies were eligible and then extracted data. Risk of bias was assessed using standard Cochrane methods, and relevant outcomes were extracted for each report. The primary outcome was residual kidney function (RKF). Secondary outcomes included all-cause, cardiovascular and infection-related death, infection, cardiovascular disease, hospitalisation, technique survival, life participation and fatigue.
Main results: A total of 153 reports of 84 studies (2 RCTs, 82 NRSIs) were included. Studies varied widely in design (small single-centre studies to international registry analyses) and in the included populations (broad inclusion criteria versus restricted to more specific participants). Additionally, treatment delivery (e.g. automated versus continuous ambulatory PD, HD with catheter versus arteriovenous fistula or graft, in-centre versus home HD) and duration of follow-up varied widely. The two included RCTs were deemed to be at high risk of bias in terms of blinding participants and personnel and blinding outcome assessment for outcomes pertaining to quality of life. However, most other criteria were assessed as low risk of bias for both studies. Although the risk of bias (Newcastle-Ottawa Scale) was generally low for most NRSIs, studies were at risk of selection bias and residual confounding due to the constraints of the observational study design. In children, there may be little or no difference between HD and PD on all-cause death (6 studies, 5752 participants: RR 0.81, 95% CI 0.62 to 1.07; I2 = 28%; low certainty) and cardiovascular death (3 studies, 7073 participants: RR 1.23, 95% CI 0.58 to 2.59; I2 = 29%; low certainty), and was unclear for infection-related death (4 studies, 7451 participants: RR 0.98, 95% CI 0.39 to 2.46; I2 = 56%; very low certainty). In adults, compared with HD, PD had an uncertain effect on RKF (mL/min/1.73 m2) at six months (2 studies, 146 participants: MD 0.90, 95% CI 0.23 to 3.60; I2 = 82%; very low certainty), 12 months (3 studies, 606 participants: MD 1.21, 95% CI -0.01 to 2.43; I2 = 81%; very low certainty) and 24 months (3 studies, 334 participants: MD 0.71, 95% CI -0.02 to 1.48; I2 = 72%; very low certainty). PD had uncertain effects on residual urine volume at 12 months (3 studies, 253 participants: MD 344.10 mL/day, 95% CI 168.70 to 519.49; I2 = 69%; very low certainty). PD may reduce the risk of RKF loss (3 studies, 2834 participants: RR 0.55, 95% CI 0.44 to 0.68; I2 = 17%; low certainty). Compared with HD, PD had uncertain effects on all-cause death (42 studies, 700,093 participants: RR 0.87, 95% CI 0.77 to 0.98; I2 = 99%; very low certainty). In an analysis restricted to RCTs, PD may reduce the risk of all-cause death (2 studies, 1120 participants: RR 0.53, 95% CI 0.32 to 0.86; I2 = 0%; moderate certainty). PD had uncertain effects on both cardiovascular (21 studies, 68,492 participants: RR 0.96, 95% CI 0.78 to 1.19; I2 = 92%) and infection-related death (17 studies, 116,333 participants: RR 0.90, 95% CI 0.57 to 1.42; I2 = 98%) (both very low certainty). Compared with HD, PD had uncertain effects on the number of patients experiencing bacteraemia/bloodstream infection (2 studies, 2582 participants: RR 0.34, 95% CI 0.10 to 1.18; I2 = 68%) and the number of patients experiencing infection episodes (3 studies, 277 participants: RR 1.23, 95% CI 0.93 to 1.62; I2 = 20%) (both very low certainty). PD may reduce the number of bacteraemia/bloodstream infection episodes (2 studies, 2637 participants: RR 0.44, 95% CI 0.27 to 0.71; I2 = 24%; low certainty). Compared with HD; It is uncertain whether PD reduces the risk of acute myocardial infarction (4 studies, 110,850 participants: RR 0.90, 95% CI 0.74 to 1.10; I2 = 55%), coronary artery disease (3 studies, 5826 participants: RR 0.95, 95% CI 0.46 to 1.97; I2 = 62%); ischaemic heart disease (2 studies, 58,374 participants: RR 0.86, 95% CI 0.57 to 1.28; I2 = 95%), congestive heart failure (3 studies, 49,511 participants: RR 1.10, 95% CI 0.54 to 2.21; I2 = 89%) and stroke (4 studies, 102,542 participants: RR 0.94, 95% CI 0.90 to 0.99; I2 = 0%) because of low to very low certainty evidence. Compared with HD, PD had uncertain effects on the number of patients experiencing hospitalisation (4 studies, 3282 participants: RR 0.90, 95% CI 0.62 to 1.30; I2 = 97%) and all-cause hospitalisation events (4 studies, 42,582 participants: RR 1.02, 95% CI 0.81 to 1.29; I2 = 91%) (very low certainty). None of the included studies reported specifically on life participation or fatigue. However, two studies evaluated employment. Compared with HD, PD had uncertain effects on employment at one year (2 studies, 593 participants: RR 0.83, 95% CI 0.20 to 3.43; I2 = 97%; very low certainty).
Authors' conclusions: The comparative effectiveness of PD and HD on the preservation of RKF, all-cause and cause-specific death risk, the incidence of bacteraemia, other vascular complications (e.g. stroke, cardiovascular events) and patient-reported outcomes (e.g. life participation and fatigue) are uncertain, based on data obtained mostly from NRSIs, as only two RCTs were included.
Trial registration: ClinicalTrials.gov NCT01413074 NCT02378350 NCT00931970 NCT00510549 NCT04197674.
Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Conflict of interest statement
Isabelle Ethier: No relevant interests were disclosed
Ashik Hayat: No relevant interests were disclosed
Juan Pei: No relevant interests were disclosed
Carmel M Hawley: No relevant interests were disclosed
David W Johnson: Bayer (Independent Contractor ‐ Consultant), Ono (Independent Contractor ‐ Consultant), AstraZeneca (Independent Contractor ‐ Consultant), Baxter Healthcare Corporation (Independent Contractor ‐ Consultant), Amgen (Travel), Boehringer Ingelheim (Independent Contractor ‐ Other), BAXTER HEALTHCARE (Independent Contractor ‐ Consultant), AWAK (Independent Contractor ‐ Consultant), Vifor Fresenius Medical Care Renal Pharma Ltd. (Independent Contractor ‐ Consultant)
Ross S Francis: Exelixis Inc. (Independent Contractor ‐ Consultant)
Germaine Wong: No relevant interests were disclosed
Jonathan C Craig: No relevant interests were disclosed
Andrea K Viecelli: No relevant interests were disclosed
Yeoungjee Choi: Vifor Fresenius Medical Care Renal Pharma Ltd. (Grant / Contract), Baxter Healthcare Corporation (Grant / Contract), Baxter Healthcare Corporation (Grant / Contract)
Htay Htay: BAXTER HEALTHCARE (Independent Contractor ‐ Consultant), AWAK (Independent Contractor ‐ Consultant
Samantha Ng: No relevant interests were disclosed
Saskia Leibowitz: No relevant interests were disclosed
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- Noordzij M, Voormolen NM, Boeschoten EW, Dekker FW, Bos WJ, Krediet RT, et al. Disordered mineral metabolism is not a risk factor for loss of residual renal function in dialysis patients. Nephrology Dialysis Transplantation 2009;24(5):1580–7. [PMID: ] - PubMed
-
- Termorshuizen F, Korevaar JC, Dekker FW, Van Manen JG, Boeschoten EW, Krediet RT. Hemodialysis and peritoneal dialysis: comparison of adjusted mortality rates according to the duration of dialysis: analysis of The Netherlands Cooperative Study on the Adequacy of Dialysis 2. Journal of the American Society of Nephrology 2003;14(11):2851-60. [PMID: ] - PubMed
Nitsch 2011 {published data only}
-
- Nitsch D, Steenkamp R, Tomson CR, Roderick P, Ansell D, MacGregor MS. Outcomes in patients on home haemodialysis in England and Wales, 1997-2005: a comparative cohort analysis. Nephrology Dialysis Transplantation 2011;26(5):1670-7. [PMID: ] - PubMed
Nordio 2012 {published data only}
-
- Nordio M, Limido A, Maggiore U, Nichelatti M, Postorino M, Quintaliani G, et al. Survival in patients treated by long-term dialysis compared with the general population. American Journal of Kidney Diseases 2012;59(6):819-28. [PMID: ] - PubMed
-
- Nordio M, Tessitore N, Feriani M, Rossi B, Virga G, Amici G, et al. Mortality in the Veneto population on renal replacement therapy. Journal of Nephrology 2013;26 Suppl 20:S23-33. [PMID: ] - PubMed
Quinn 2011 {published data only}
Quinn 2014 {published data only}
REIN 2011 {published data only}
-
- Levy B, Couchoud C, Rougier JP, Jourde-Chiche N, Daugas E. Outcome of patients with systemic lupus erythematosus on chronic dialysis: an observational study of incident patients of the French National Registry 2002-2012. Lupus 2015;24(10):1111-21. [PMID: ] - PubMed
-
- Sens F, Schott-Pethelaz AM, Labeeuw M, Colin C, Villar E. Survival advantage of hemodialysis relative to peritoneal dialysis in patients with end-stage renal disease and congestive heart failure. Kidney International 2011;80(9):970-7. [PMID: ] - PubMed
-
- Thiery A, Severac F, Hannedouche T, Couchoud C, Do VH, Tiple A, et al. Survival advantage of planned haemodialysis over peritoneal dialysis: a cohort study. Nephrology Dialysis Transplantation 2018;33(8):1411-9. [PMID: ] - PubMed
Rydell 2019 {published data only}
Saka 2017 {published data only}
-
- Saka Y, Naruse T, Tawada N, Tokomoto M, Noda Y, Taniguchi Y, et al. Quality of life of elderly patients on peritoneal dialysis versus hemodialysis: a single-center study. Clinical & Experimental Nephrology 2017;21(5):919-25. [PMID: ] - PubMed
Sanabria 2008 {published data only}
-
- Sanabria M, Muoz J, Trillos C, Hernandez G, Latorre C, Diaz CS, et al. Dialysis outcomes in Colombia (DOC) study: a comparison of patient survival on peritoneal dialysis vs hemodialysis in Colombia. Kidney International - Supplement 2008;73(108):S165-72. [PMID: ] - PubMed
SINGAPORE {published data only}
-
- Panday VB, Tong ZP, Ng PL, Lee EJ, Lau T, Teo BW, et al. Dialysis modality and 2-year outcomes in patients with ischemic cardiomyopathy and end-stage renal disease. International Journal of Cardiology 2014;176(3):1097-9. [PMID: ] - PubMed
Szuster 2012 {published data only}
-
- Szuster DA, Caiaffa WT, Andrade EI, Acurcio Fde A, Cherchiglia ML. Survival analysis of dialysis patients in the Brazilian Unified National Health System [Sobrevida de pacientes em dialise no SUS no Brasil]. Cadernos de Saude Publica 2012;28(3):415-24. [PMID: ] - PubMed
TAIWAN {published data only}
-
- Chen HJ, Wang JJ, Tsay WI, Her SH, Lin CH, Chien CC. Epidemiology and outcome of acute pancreatitis in end-stage renal disease dialysis patients: a 10-year national cohort study. Nephrology Dialysis Transplantation 2017;32(10):1731-6. [PMID: ] - PubMed
-
- Chen YJ, Kung PT, Wang YH, Huang CC, Hsu SC, Tsai WC, et al. Greater risk of hip fracture in hemodialysis than in peritoneal dialysis. Osteoporosis International 2014;25(5):1513-8. [PMID: ] - PubMed
-
- Hu PJ, Chen YW, Chen TT, Sung LC, Wu MY, Wu MS. Impact of dialysis modality on major adverse cardiovascular events and all-cause mortality: a national population-based study. Nephrology Dialysis Transplantation 2021;36(5):901-8. [PMID: ] - PubMed
-
- Hung YM, Chen YY, Huang WC, Wang PYP, Chou P, Lai YJ. Association between dialysis modalities and risk of coronary artery disease: a population-based cohort study in Taiwan. Therapeutic Apheresis & Dialysis 2018;22(5):469-75. [PMID: ] - PubMed
-
- Lin ZZ, Wang JJ, Chung CR, Huang PC, Su BA, Cheng KC, et al. Epidemiology and mortality of hip fracture among patients on dialysis: Taiwan National Cohort Study. Bone 2014;64:235-9. [PMID: ] - PubMed
Tamayo Isla 2016 {published data only}
-
- Tamayo Isla RA, Ameh OI, Mapiye D, Swanepoel CR, Bello AK, Ratsela AR, et al. Baseline predictors of mortality among predominantly rural-dwelling end-stage renal disease patients on chronic dialysis therapies in Limpopo, South Africa. PLoS ONE [Electronic Resource] 2016;11(6):e0156642. [PMID: ] - PMC - PubMed
Teruel‐Briones 2013 {published data only}
-
- Teruel-Briones JL, Fernandez-Lucas M, Rivera-Gorrin M, Ruiz-Roso G, Diaz-Dominguez M, Rodriguez-Mendiola N, et al. Progression of residual renal function with an increase in dialysis: haemodialysis versus peritoneal dialysis. Nefrologia 2013;33(5):640-9. [PMID: ] - PubMed
Traynor 2011 {published data only}
-
- Traynor JP, Thomson PC, Simpson K, Ayansina DT, Prescott GJ, Mactier RA. Comparison of patient survival in non-diabetic transplant-listed patients initially treated with haemodialysis or peritoneal dialysis. Nephrology Dialysis Transplantation 2011;26(1):245-52. [PMID: ] - PubMed
Tsai 2019 {published data only}
-
- Tsai WT, Chang HC, Wang CT, Chiang BL, Lin YT. Long-term outcomes in lupus patients receiving different renal replacement therapy. Journal of Microbiology, Immunology, & Infection 2019;52(4):648-53. [PMID: ] - PubMed
Tse 2003 {published data only}
-
- Tse KC, Lui SL, Lo WK. Comparison of long-term survival (beyond 12 years) in patients on peritoneal dialysis and on hemodialysis. Peritoneal Dialysis International 2003;23 Suppl 2:S104-8. [PMID: ] - PubMed
Uchida 2007 {published data only}
-
- Uchida K, Shoda J, Sugahara S, Ikeda N, Kobayashi K, Kanno Y, et al. Comparison and survival of patients receiving hemodialysis and peritoneal dialysis in a single center. Advances in Peritoneal Dialysis 2007;23:144-9. [PMID: ] - PubMed
Ueda 2017 {published data only}
-
- Ueda A, Iwase M, Usui T, Hirayama A, Nagai K, Saito C, et al. Peritoneal dialysis patients preserve residual renal function and reduced oxidative stress during the initial period of dialysis therapy [abstract no: MP419]. Nephrology Dialysis Transplantation 2014;29(Suppl 3):iii472-3. [EMBASE: 71492830]
-
- Ueda A, Nagai K, Hirayama A, Nagasaki Y, Yamagata K. Combination therapy with PD+HD from the initiation of renal replacement therapy preserves the residual renal function and serum albumin [abstract]. Hemodialysis International 2017;21(1):A30. [EMBASE: 614510747]
-
- Ueda A, Nagai K, Hirayama A, Saito C, Yamagata K. Combination therapy with peritoneal dialysis and hemodialysis from the initiation of renal replacement therapy preserves residual renal function and serum albumin. Advances in Peritoneal Dialysis 2017;33(2017):74-8. [PMID: ] - PubMed
-
- Ueda A, Nagai K, Hirayama A, Saito C, Yamagata K. Peritoneal dialysis preserves residual renal function and reduces oxidative stress during the initial period of dialysis therapy. Advances in Peritoneal Dialysis 2017;33(2017):18-21. [PMID: ] - PubMed
USRDS 1995‐2000 {published data only}
-
- Ahuja TS, Collinge N, Grady J, Khan S. Is dialysis modality a factor in survival of patients with ESRD and HIV-associated nephropathy? American Journal of Kidney Diseases 2003;41(5):1060-4. [PMID: ] - PubMed
-
- Collins AJ, Weinhandl E, Snyder JJ, Chen SC, Gilbertson D. Comparison and survival of hemodialysis and peritoneal dialysis in the elderly. Seminars in Dialysis 2002;15(2):98-102. [PMID: ] - PubMed
-
- Stack AG, Murthy BV, Molony DA. Survival differences between peritoneal dialysis and hemodialysis among "large" ESRD patients in the United States. Kidney International 2004;65(6):2398-408. [PMID: ] - PubMed
-
- Vonesh EF, Snyder JJ, Foley RN, Collins AJ. The differential impact of risk factors on mortality in hemodialysis and peritoneal dialysis. Kidney International 2004;66(6):2389-401. [PMID: ] - PubMed
-
- Xue JL, Everson SE, Constantini EG, Ebben JP, Chen SC, Agodoa LY, et al. Peritoneal and hemodialysis: II. Mortality risk associated with initial patient characteristics. Kidney International 2002;61(2):741-6. [PMID: ] - PubMed
USRDS 2001‐2006 {published data only}
Vacaroiu 2012 {published data only}
-
- Vacaroiu IA, Radulescu D, Ciocalteu A, Peride I, Ardeleanu S, Checherita IA. Functional status of chronic renal replacement therapy in elderly patients--comparison between hemodialysis and peritoneal dialysis. Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 2012;361(16):375-82. [PMID: ] - PubMed
Van Biesen 2000 {published data only}
-
- Van Biesen W, Vanholder RC, Veys N, Dhondt A, Lameire NH. An evaluation of an integrative care approach for end-stage renal disease patients. Journal of the American Society of Nephrology 2000;11(1):116-25. [PMID: ] - PubMed
van de Luijtgaarden 2011 {published data only}
-
- de Luijtgaarden MW, Noordzij M, Stel VS, Ravani P, Jarraya F, Collart F, et al. Effects of comorbid and demographic factors on dialysis modality choice and related patient survival in Europe. Nephrology Dialysis Transplantation 2011;26(9):2940-7. [PMID: ] - PubMed
Waldum‐Grevbo 2015 {published data only}
Weinhandl 2010 {published data only}
Weinhandl 2016 {published data only}
-
- Weinhandl ED, Gilbertson DT, Collins AJ. Mortality, hospitalization, and technique failure in daily home hemodialysis and matched peritoneal dialysis patients: a matched cohort study. American Journal of Kidney Diseases 2016;67(1):98-110. [PMID: ] - PubMed
Wu 2014 {published data only}
-
- Wu B, Wang M, Gan L, Zhao H. Comparison of patient survival between hemodialysis and peritoneal dialysis in a single Chinese center. International Urology & Nephrology 2014;46(12):2403-7. [PMID: ] - PubMed
Xu 2023 {published data only}
-
- Xu F, Yang Y, Wu M, Zhou W, Wang D, Cui W. Patients with end-stage renal disease and diabetes had similar survival rates whether they received hemodialysis or peritoneal dialysis. Therapeutic Apheresis & Dialysis 2023;27(1):59-65. [PMID: ] - PubMed
Yao 2020 {published data only}
Yong 2014 {published data only}
-
- Yong K, Dogra G, Boudville N, Lim W. Increased inflammatory response in association with the initiation of hemodialysis compared with peritoneal dialysis in a prospective study of end-stage kidney disease patients. Peritoneal Dialysis International 2018;38(1):18-23. [PMID: ] - PubMed
-
- Yong K, Dogra G, Boudville N, Lim W. The effects of dialysis modality upon inflammation in predialysis end-stage renal disease patients [abstract]. Nephrology 2016;21(Suppl 2):47‐8. [EMBASE: 612312815]
-
- Yong K, Dogra G, Boudville N, Lim WH. Improvements in arterial stiffness are associated with changes in blood pressure but not dialysis modality in incident dialysis patients [abstract no: 072]. Nephrology 2014;19(Suppl 4):36. [EMBASE: 71587852]
References to studies excluded from this review
Abderrahim 2001 {published data only}
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- Abderrahim E, Zouaghi K, Hedri H, Ben Abdallah T, Ben Hamida F, Kaaroud H, et al. Renal replacement therapy for diabetic end-stage renal disease. Experience of a Tunisian hospital centre. Diabetes & Metabolism 2001;27((5 Pt 1)):584-90. [PMID: ] - PubMed
Adeniyi 2009 {published data only}
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- Adeniyi M, Kassam H, Agaba EI, Sun Y, Servilla KS, Raj DS, et al. Hospitalizations in patients treated sequentially by chronic hemodialysis and continuous peritoneal dialysis. Advances in Peritoneal Dialysis 2009;25:72-5. [PMID: ] - PubMed
Al‐Jahdali 2009 {published data only}
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- Al-Jahdali HH, Al-Qadhi WA, Khogeer HA, Al-Hejaili FF, Al-Ghamdi SM, Al Sayyari AA. Restless legs syndrome in patients on dialysis. Saudi Journal of Kidney Diseases & Transplantation 2009;20(3):378-85. [PMID: ] - PubMed
Alvares 2013 {published data only}
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- Alvares J, Almeida AM, Szuster DA, Gomes IC, Andrade EI, Acurio Fde A, et al. Factors associated with quality of life in patients in renal replacement therapy in Brazil [Fatores associados a qualidade de vida de pacientes em terapia renal substitutiva no Brasil]. Ciencia & Saude Coletiva 2013;18(7):1903-10. [PMID: ] - PubMed
Al‐Wakeel 2002 {published data only}
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- Al Wakeel JS, Mitwalli AH, Al Mohaya S, Abu-Aisha H, Tarif N, Malik GH, et al. Morbidity and mortality in ESRD patients on dialysis. Saudi Journal of Kidney Diseases & Transplantation 2002;13(4):473-7. [PMID: ] - PubMed
Ansell 2009 {published data only}
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- Ansell D, Roderick P, Hodsman A, Ford D, Steenkamp R, Tomson C. UK Renal Registry 11th Annual Report (December 2008): Chapter 7 Survival and causes of death of UK adult patients on renal replacement therapy in 2007: national and centre-specific analyses. Nephron 2009;111 Suppl 1:c113-39. [PMID: ] - PubMed
Ansell 2010 {published data only}
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- Ansell D, Roderick P, Steenkamp R, Tomson CR. UK Renal Registry 12th Annual Report (December 2009): chapter 7: survival and causes of death of UK adult patients on renal replacement therapy in 2008: national and centre-specific analyses. Nephron 2010;115 Suppl 1:c117-44. [PMID: ] - PubMed
Antoun 2023 {published data only}
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- Antoun J, Brown DJ, Jones DJ, Clarkson BG, Shepherd AI, Sangala NC, et al. Exploring patients' experiences of the impact of dialysis therapies on quality of life and wellbeing. Journal of Renal Care 2023;49(1):15-23. [PMID: ] - PubMed
Ashman 2003 {published data only}
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- Ashman N, Macey MG, Fan SL, Azam U, Yaqoob MM. Increased platelet-monocyte aggregates and cardiovascular disease in end-stage renal failure patients. Nephrology Dialysis Transplantation 2003;18(10):2088-96. [PMID: ] - PubMed
Asmis 2008 {published data only}
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- Asmis LM, Segal JB, Plantinga LC, Fink NE, Kerman JS, Kickler TS, et al. Heparin-induced antibodies and cardiovascular risk in patients on dialysis. Thrombosis & Haemostasis 2008;100(3):498-504. [PMID: ] - PubMed
Atalay 2002 {published data only}
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- Atalay S, Ekim M, Tutar HE, Kocak G, Bakkaloglu S, Tumer N. Systolic and diastolic function in children with chronic renal failure. Pediatrics International 2002;44(1):18-23. [PMID: ] - PubMed
Back 2017 {published data only}
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- Back C, Hornum M, Moller CJH, Olsen PS. Cardiac surgery in patients with end-stage renal disease on dialysis. Scandinavian Cardiovascular Journal 2017;56(1):334-8. [PMID: ] - PubMed
Bakewell 2001 {published data only}
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- Bakewell AB, Higgins RM, Edmunds ME. Does ethnicity influence perceived quality of life of patients on dialysis and following renal transplant? Nephrology Dialysis Transplantation 2017;16(7):1395-401. [PMID: ] - PubMed
Barata 2015 {published data only}
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- Barata NE. Dyadic relationship and quality of life patients with chronic kidney disease. Jornal Brasileiro de Nefrologia 2015;37(3):315-22. [PMID: ] - PubMed
Bargnoux 2020 {published data only}
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- Bargnoux AS, Buthiau D, Morena M, Rodriguez A, Noguera-Gonzalez ME, Gilbert O, et al. Estimation of residual renal function using beta-trace protein: Impact of dialysis procedures. Artificial Organs 2020;44(6):647-54. [PMID: ] - PubMed
Barrah 2021 {published data only}
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- Barrah S, Kheder RE, Jebali H, Krid M, Smaoui W, Beji S, et al. Comparison of changes in pulse wave velocity in patients on peritoneal dialysis and hemodialysis. Saudi Journal of Kidney Diseases & Transplantation 2021;32(2):336-340. [PMID: ] - PubMed
Basok 2009 {published data only}
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- Basok EK, Atsu N, Rifaioglu MM, Kantarci G, Yildirim A, Tokuc R. Assessment of female sexual function and quality of life in predialysis, peritoneal dialysis, hemodialysis, and renal transplant patients. International Urology & Nephrology 2009;41(3):473-81. [PMID: ] - PubMed
Beanes 2000 {published data only}
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- Beanes SR, Kling KM, Fonkalsrud EW, Torres M, Salusky IB, Quinones-Baldrich WJ, et al. Surgical aspects of dialysis in newborns and infants weighing less than ten kilograms. Journal of Pediatric Surgery 2000;35(11):1543-8. [PMID: ] - PubMed
Beaumier 2020 {published data only}
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- Beaumier M, Bechade C, Dejardin O, Lassalle M, Vigneau C, Longlune N, et al. Is self-care dialysis associated with social deprivation in a universal health care system? A cohort study with data from the Renal Epidemiology and Information Network Registry. Nephrology Dialysis Transplantation 2020;35(5):861-9. [PMID: ] - PubMed
Bohlke 2008 {published data only}
Borazan 2004 {published data only}
Caliskan 2009 {published data only}
-
- Caliskan Y, Yazici H, Gorgulu N, Yelken B, Emre T, Turkmen A, et al. Effect of pre-transplant dialysis modality on kidney transplantation outcome. Peritoneal Dialysis International 2009;29 Suppl 2:S117-22. [PMID: ] - PubMed
Chavers 2015 {published data only}
Chen 2018 {published data only}
Chilcot 2011 {published data only}
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- Chilcot J, Davenport A, Wellsted D, Firth J, Farrington K. An association between depressive symptoms and survival in incident dialysis patients. Nephrology Dialysis Transplantation 2011;26(5):1628-34. [PMID: ] - PubMed
Chou 2010 {published data only}
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- Chou CY, Wang IK, Liu JH, Lin HH, Wang SM, Huang CC. Comparing survival between peritoneal dialysis and hemodialysis treatment in ESRD patients with chronic hepatitis C infection. 2010 Peritoneal Dialysis International;30(1):86-90. [PMID: ] - PubMed
Chung 2011 {published data only}
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- Chung BH, Lee JY, Kang SH, Sun IO, Choi SR, Park HS, et al. Comparison of patient outcome according to renal replacement modality after renal allograft failure. Renal Failure 2011;33(3):261-8. [PMID: ] - PubMed
Czyzewski 2014 {published data only}
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- Czyzewski L, Sanko-Resmer J, Wyzgal J, Kurowski A. Assessment of health-related quality of life of patients after kidney transplantation in comparison with hemodialysis and peritoneal dialysis. Annals of Transplantation 2014;19:576-85. [PMID: ] - PubMed
Da Silva‐Gane 2012 {published data only}
de Jonge 2006 {published data only}
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- Jonge H, Bammens B, Lemahieu W, Maes BD, Vanrenterghem Y. Comparison of peritoneal dialysis and haemodialysis after renal transplant failure. Transplantation Proceedings 2006;45(8):1669-74. [PMID: ] - PubMed
de Wit 2002 {published data only}
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- Wit GA, Merkus MP, Krediet RT, Charro FT. Health profiles and health preferences of dialysis patients. Nephrology Dialysis Transplantation 2002;17(1):86-92. [PMID: ] - PubMed
Dipalma 2016 {published data only}
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- Dipalma T, Fernandez-Ruiz M, Praga M, Polanco N, Gonzalez E, Gutierrez-Solis E, et al. Pre-transplant dialysis modality does not influence short- or long-term outcome in kidney transplant recipients: analysis of paired kidneys from the same deceased donor. Clinical Transplantation 2016;30(9):1097-107. [PMID: ] - PubMed
Donate 2002 {published data only}
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- Donate T, Herreros A, Martinez E, Martinez J, Andres E, Cabezas A, et al. Protein oxidative stress in dialysis patients. Advances in Peritoneal Dialysis 2002;18:15-7. [PMID: ] - PubMed
Dozio 2018 {published data only}
Eiselt 2010 {published data only}
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- Eiselt J, Rajdl D, Racek J, Siroka R, Trefil L, Opatrna S. Asymmetric dimethylarginine in hemodialysis, hemodiafiltration, and peritoneal dialysis. Artificial Organs 2010;34(5):420-5. [PMID: ] - PubMed
Evenepoel 2016 {published data only}
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- Evenepoel P, Meijers BKI, Bammens B, Viaene L, Claes K, Sprangers B, et al. Phosphorus metabolism in peritoneal dialysis- and haemodialysis-treated patients. Nephrology Dialysis Transplantation 2016;31(9):1508-14. [PMID: ] - PubMed
Fassett 2009 {published data only}
Fernandes 2023 {published data only}
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- Fernandes A, Matias P, Branco P. Incremental peritoneal dialysis: Is it better for preservation of residual kidney function and clinical outcomes? Clinical Nephrology 2023;99(1):11-7. [PMID: ] - PubMed
Fernandez Lucas 2007 {published data only}
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- Fernandez Lucas M, Teruel JL, Zamora J, Lopez Mateos M, Rivera M, Ortuno J. A Mediterranean age-comorbidity prognostic index for survival in dialysis populations. Journal of Nephrology 2007;20(6):696-702. [PMID: ] - PubMed
Ferreira 2020 {published data only}
Fischer 2016 {published data only}
Fishbane 2022 {published data only}
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- Fishbane S, Pollock CA, El-Shahawy M, Escudero ET, Rastogi A, Van BP, et al. Roxadustat versus epoetin alfa for treating anemia in patients with chronic kidney disease on dialysis: results from the randomized phase 3 ROCKIES study. Journal of the American Society of Nephrology 2022;33(4):850-66. [MEDLINE: ] - PMC - PubMed
Foley 2004 {published data only}
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- Foley RN, Guo H, Snyder JJ, Gilbertson DT, Collins AJ. Septicemia in the United States dialysis population, 1991 to 1999. Journal of the American Society of Nephrology 2004;15(4):1038-45. [PMID: ] - PubMed
Gama‐Axelsson 2013 {published data only}
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- Gama-Axelsson T, Lindholm B, Barany P, Heimburger O, Stenvinkel P, Qureshi AR. Self-rated appetite as a predictor of mortality in patients with stage 5 chronic kidney disease. Journal of Renal Nutrition 2013;23(2):106-13. [PMID: ] - PubMed
Glanton 2003 {published data only}
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- Glanton CW, Hypolite IO, Hshieh PB, Agodoa LY, Yuan CH, Abbott KC. Factors associated with improved short term survival in obese end stage renal disease patients. Annals of Epidemiology 2003;13(2):136-43. [PMID: ] - PubMed
Gouveia 2017 {published data only}
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- Gouveia DS, Bignelli AT, Hokazono SR, Danucalov I, Siemens TA, Meyer F, et al. Analysis of economic impact between the modality of renal replacement therapy. Jornal Brasileiro de Nefrologia 2017;39(2):162-71. [PMID: ] - PubMed
Griffith 2003 {published data only}
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- Griffith TF, Chua BS, Allen AS, Klassen PS, Reddan DN, Szczech LA. Characteristics of treated hypertension in incident hemodialysis and peritoneal dialysis patients. American Journal of Kidney Diseases 2003;42(6):1260-9. [PMID: ] - PubMed
Gruppen 2003 {published data only}
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- Gruppen MP, Groothoff JW, Prins M, Wouw P, Offringa M, Bos WJ, et al. Cardiac disease in young adult patients with end-stage renal disease since childhood: a Dutch cohort study. Kidney International 2003;63(3):1058-65. [PMID: ] - PubMed
Guerrero Riscos 2019 {published data only}
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- Guerrero Riscos MA, Toro Prieto FJ, Batalha Caetano P, Salgueira Lazo M, Gonzalez Cabrera F, Marrero Robayna S, et al. Advanced chronic renal failure (ACRF) study. Baseline characteristics, evaluation of the application of the structured information for the election of renal replacement therapy and one-year evolution of the incident patients in the ACRF medical office [Estudio ERCA. Caracteristicas basales, evaluacion de la aplicacion de la informacion estructurada para la eleccion de tratamiento renal sustitutivo y evolucion a un ano de los pacientes incidentes en la consulta ERCA]. Nefrologia 2019;39(6):629-37. [PMID: ] - PubMed
Guo 2008 {published data only}
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- Guo H, Liu J, Collins AJ, Foley RN. Pneumonia in incident dialysis patients--the United States Renal Data System. Nephrology Dialysis Transplantation 2008;23(2):680-6. [PMID: ] - PubMed
Haller 2011 {published data only}
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- Haller M, Gutjahr G, Kramar R, Harnoncourt F, Oberbauer R. Cost-effectiveness analysis of renal replacement therapy in Austria. Nephrology Dialysis Transplantation 2011;26(9):2988-95. [PMID: ] - PubMed
Harris 2002 {published data only}
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- Harris SA, Lamping DL, Brown EA, Constantinovici N. Clinical outcomes and quality of life in elderly patients on peritoneal dialysis versus hemodialysis. Peritoneal Dialysis International 2002;22(4):463-70. [PMID: ] - PubMed
Haynes 2012 {published data only}
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- Haynes R, Kheradmand F, Winearls CG. Survival after starting renal replacement treatment in patients with autosomal dominant polycystic kidney disease: a single-centre 40-year study. Nephron 2012;120(1):c42-7. [PMID: ] - PubMed
Hong 2014 {published data only}
Iacovides 2002 {published data only}
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- Iacovides A, Fountoulakis KN, Balaskas E, Manika A, Markopoulou M, Kaprinis G, et al. Relationship of age and psychosocial factors with biological ratings in patients with end-stage renal disease undergoing dialysis. Aging-Clinical & Experimental Research 2002;14(5):354-60. [PMID: ] - PubMed
IDEAL‐Dialysis 2004 {published data only}
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- Brunkhorst R. Early versus late initiation of dialysis. New England Journal of Medicine 2010;363(24):2368-70. [MEDLINE: ] - PubMed
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- Collins J, Cooper B, Branley P, Bulfone L, Craig J, Fraenkel M, et al. Outcomes of patients with planned initiation of hemodialysis in the IDEAL trial. Contributions to Nephrology 2011;171:1-9. [MEDLINE: ] - PubMed
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- Cooper B, Branley P, Bulfone L, Collins J, Craig J, Fraenkel M, et al. The results of the initiating dialysis early and late trial [abstract no: 166]. Nephrology 2010;15(Suppl 4):70. [EMBASE: 70467170]
-
- Cooper B. Are patients randomized in the IDEAL trial representative of the Australia-New Zealand dialysis population? [abstract no: 031]. Nephrology 2008;13(Suppl 3):A101.
-
- Cooper BA, Branley P, Bulfone L, Collins JF, Craig JC, Dempster J, et al. The initiating dialysis early and late (IDEAL) study: study rationale and design. Peritoneal Dialysis International 2004;24(2):176-81. [MEDLINE: ] - PubMed
Iseri 2020 {published data only}
-
- Iseri K, Carrero JJ, Evans M, Fellander-Tsai L, Berg H, Runesson B, et al. Major fractures after initiation of dialysis: Incidence, predictors and association with mortality. Bone 2020;133:115242. [PMID: ] - PubMed
Ishani 2005 {published data only}
-
- Ishani A, Collins AJ, Herzog CA, Foley RN. Septicemia, access and cardiovascular disease in dialysis patients: the USRDS Wave 2 study. 2005 Kidney International;68(1):311-8. [PMID: ] - PubMed
Jain 2009 {published data only}
-
- Jain P, Cockwell P, Little J, Ferring M, Nicholas J, Richards N, et al. Survival and transplantation in end-stage renal disease: a prospective study of a multiethnic population. Nephrology Dialysis Transplantation 2009;24(12):3840-6. [PMID: ] - PubMed
Jain 2022 {published data only}
Jeon 2019 {published data only}
Jhamb 2009 {published data only}
Johansen 2004 {published data only}
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- Johansen KL, Young B, Kaysen GA, Chertow GM. Association of body size with outcomes among patients beginning dialysis. American Journal of Clinical Nutrition 2004;80(2):324-32. [PMID: ] - PubMed
Jung 2022 {published data only}
Kayalar 2016 {published data only}
Kim 2011 {published data only}
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Kubo 2022 {published data only}
Kutner 2000 {published data only}
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Li 2023 {published data only}
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- Li X, Shi B, Chen X, Duan J, Liu X, Zhang R, et al. Fragmented QRS complex on a 12-lead electrocardiogram predicts cardiovascular and all-cause mortality in dialysis patients. Seminars in Dialysis 2023;36(1):43-52. [PMID: ] - PubMed
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- Lobbedez T, Cousin M, Hurault de Ligny B, Ficheux M, El Haggan W, Ryckelynck JP. Failed transplant patients: dialysis initiation and short-term outcome [Dialyse apres echec de transplantation. Conditions de prise en charge initiale et evolution a court terme]. Nephrologie & Therapeutique 2009;5(3):188-92. [PMID: ] - PubMed
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- Maglakelidze N, Pantsulaia T, Tchokhonelidze I, Managadze L, Chkhotua A. Assessment of health-related quality of life in renal transplant recipients and dialysis patients. Transplantation Proceedings 2011;43(1):376-9. [PMID: ] - PubMed
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Masson 2016 {published data only}
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- Mesquita M, Guillaume MP, Standaert M, Rossez N, Vereerstraeten P, Dratwa M. Prognosis of HIV infected sub-Saharan patients on renal replacement therapy (RRT) in Brussels, Belgium: a single centre retrospective pilot study and review of the literature. Acta Clinica Belgica 2013;68(2):92-6. [PMID: ] - PubMed
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Moore 2022 {published data only}
Muehrer 2011 {published data only}
Murashima 2023 {published data only}
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Park 2015 {published data only}
Pecoits‐Filho 2002 {published data only}
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Pei 2019 {published data only}
Ponte 2020 {published data only}
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Rokhman 2023 {published data only}
Rouveure 2016 {published data only}
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Shdaifat 2022 {published data only}
Singh 2022 {published data only}
Song 2023 {published data only}
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Sun 2022 {published data only}
Suttorp 2013 {published data only}
Suzuki 2003 {published data only}
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- Suzuki T, Kanno Y, Nakamoto H, Okada H, Sugahara S, Suzuki H. Peritoneal dialysis versus hemodialysis: a five-year comparison of survival and effects on the cardiovascular system, erythropoiesis, and calcium metabolism. Advances in Peritoneal Dialysis 2003;19:148-54. [PMID: ] - PubMed
Thong 2007 {published data only}
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Tommel 2021 {published data only}
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- Tommel J, Evers AW, Hamersvelt HW, Jordens R, Dijk S, Hilbrands LB, et al. Predicting health-related quality of life in dialysis patients: factors related to negative outcome expectancies and social support. Patient Education & Counseling 2021;104(6):1474-80. [PMID: ] - PubMed
Tommel 2023 {published data only}
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- Tommel J, Evers AWM, Hamersvelt HW, Jordens R, Dijk S, Hilbrands LB, et al. "What matters to you?": The relevance of patient priorities in dialysis care for assessment and clinical practice. Seminars in Dialysis 2023;36(2):131-41. [PMID: ] - PubMed
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van Loon 2019 {published data only}
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Yeter 2023 {published data only}
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Yin 2022 {published data only}
Yongsiri 2014 {published data only}
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References to studies awaiting assessment
Arogundade 2005 {published data only}
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- Arogundade FA, Ishola DA Jr, Sanusi AA, Akinsola A. An analysis of the effectiveness and benefits of peritoneal dialysis and haemodialysis using Nigerian made PD fluids. African Journal of Medicine & Medical Sciences 2005;34(3):227-33. [MEDLINE: ] - PubMed
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References to ongoing studies
NCT04197674 {published data only}
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