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Review
. 2024 Jun 20;20(6):e1012286.
doi: 10.1371/journal.ppat.1012286. eCollection 2024 Jun.

Reactive astrocytes in prion diseases: Friend or foe?

Natallia Makarava  1   2 , Rajesh Kushwaha  1   2 , Ilia V Baskakov  1   2
Affiliations
Review

Reactive astrocytes in prion diseases: Friend or foe?

Natallia Makarava et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic diagram illustrating interaction between microglia, astrocytes, endothelial cells, and neurons in prion diseases.
PrPSc triggers proinflammatory phenotype in microglia [40]. Reactive microglia activate astrocytes [7]. In reactive state, astrocytes lose homeostatic functions that support neurons [9]. Reactive astrocytes associated with prion disease are neurotoxic [7] and have deleterious effects on endothelial cells of BBB [8].
Fig 2
Fig 2. Principle component analysis (PCA) of region-specific differences in expression of astrocyte specific across 5 animal groups: prion-infected mice, mice subjected to TBI, 5XFAD mouse model of Alzheimer’s disease, mice subjected to ischemic insult (MCAO, middle cerebral artery occlusion), and aged 24-month-old mice.
Cortex, hippocampus, thalamus, and hypothalamus were analyzed in each group. PCA revealed well resolved continuums of astrocytic phenotypes shown on bottom right: one shared by the cortex and hippocampus and another by the thalamus and hypothalamus. Each dot represents an individual animal. The figure was adapted from [21].
See this image and copyright information in PMC

References

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