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Editorial
. 2024 Jun 21;135(1):57-59.
doi: 10.1161/CIRCRESAHA.124.324791. Epub 2024 Jun 20.

EnFUSiasm for Healing: Ultrasound Neuromodulation in PAH

Olga Rafikova  1 , Joel James  1 , Tatiana V Kudryashova  2
Affiliations
Editorial

EnFUSiasm for Healing: Ultrasound Neuromodulation in PAH

Olga Rafikova et al. Circ Res. .
No abstract available

Keywords: Editorials; cardiovascular diseases; inflammation; pulmonary arterial hypertension; spleen; vascular remodeling.

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Conflict of interest statement

Disclosures None.

Figures

Figure 1.
Figure 1.
Focused ultrasound stimulation of the spleen (sFUS) is a promising therapeutic approach to attenuate experimental PH. Retrospective meta-analysis of human clinical studies indicates that splenectomy is associated with a higher risk of PAH development. FUS application alleviates the severity of experimental PH in the SuHx-induced rat model, as shown by decreased RVSP, improved RV function, and PA remodeling, and alters the immune response in the spleen and lung. Preemptive splenic nerve denervation worsens the SuHx induced PH in rats and abolishes the sFUS therapeutic effect. RVSP- right ventricular systolic pressure; RAP- right atrial pressure; RV - right ventricle; BNP - brain natriuretic peptide; RVEDP - right ventricular end-diastolic pressure; TAPSE - tricuspid annular plane systolic excursion; SND - splenic nerve denervation; PH- pulmonary hypertension; SuHx – Sugen Hypoxia; scRNA-seq - single-cell RNA sequencing. TNF - tumor necrosis factor; INF - interferon; IL- interleukin.
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