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Review
. 2025 Apr;48(2):485-500.
doi: 10.1007/s10753-024-02075-6. Epub 2024 Jun 21.

The Role of Cobalamin in Multiple Sclerosis: An Update

Marjan Golabi  1 , Danial Kazemi  2 , Amir Shayan Chadeganipour  3 , Hamed Fouladseresht  1 , Mark J M Sullman  4   5 , Behrooz Ghezelbash  6 , Ava Yeganegi Dastgerdi  7 , Nahid Eskandari  8
Affiliations
Review

The Role of Cobalamin in Multiple Sclerosis: An Update

Marjan Golabi et al. Inflammation. 2025 Apr.

Abstract

Multiple sclerosis (MS) is a neurodegenerative condition that results in axonal and permanent damage to the central nervous system, necessitating healing owing to autoimmune reactions and persistent neuroinflammation. Antioxidant and anti-inflammatory drugs are essential for the management of oxidative stress and neuroinflammation. Additionally, multivitamin supplementation, particularly vitamin B12 (cobalamin), may be beneficial for neuronal protection. Although there is no documented connection between vitamin B12 deficiency and MS, researchers have explored its potential as a metabolic cause. This review highlights the therapeutic benefits of cobalamin (Cbl) in patients with MS.

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Conflict of interest statement

Declarations. Competing Interests: The authors declare no competing interests.

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