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Published Erratum
. 2024 Jun 15;16(11):10197-10198.
doi: 10.18632/aging.205986.

Correction for: The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells

Wenjia Liu  1   2 , Meng Qi  1   2 , Anna Konermann  3 , Liqiang Zhang  1 , Fang Jin  4 , Yan Jin  1   2
Affiliations
Published Erratum

Correction for: The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells

Wenjia Liu et al. Aging (Albany NY). .
No abstract available

Keywords: aging; mesenchymal stem cells; miR-17; osteogenesis; p53.

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Figures

Figure 6
Figure 6
Smurf1 plays an important role in miR-17- mediated osteogenic differentiation of BMMSCs. BMMSCs were lentivirally transduced to upregulate the expression level of P53 (= pLenti-P53) or were transduced as lentiviral control (= pLenti-Cont). miR-17 was stable upregulated in BMMSCs by miR-17 mimics (= miR-17 mimics). miRNA control (= miR Cont). 16 Mon Cont = control BMMSCs, Smurf1 siRNA = downregulated Smurf1 level via si-RNA, miR-17 inhibitor = transfection with anti-miR-17. Statistically analyzed values show the mean ± SD (n = 10). *p < 0.05. (A) Real-time PCR and western blot analysis on the expression of Smurf1 and TCF3 after upregulation of p53 (pLenti-p53) in BMMSCs derived from young mice. Normalization to β-actin. (B) Western blot analysis on the expression of Smurf1. Transfection of miR-17 mimics in stable upregulated p53 BMMSCs derived from young mice. Normalization to β- actin. (C, D) Real-time PCR and western blot analysis of Smurf1 expression in osteogenically differentiated BMMSCs from young and old mice. Normalization to β- actin. (E) Alizarin red staining after osteogenic induction for 14 d of BMMSCs derived from old mice with/without siRNA-downregulated Smurf1 level and with/without transfection with miR-17 inhibitor. (F) Western blot analysis on old BMMSCs with/without siRNA-down- regulated Smurf1 level and with/without transfection with anti-miR-17 for the osteogenic markers Runx2, ALP, osterix. Normalization to β-actin.
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