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. 2024 Jun 20;9(3):257.
doi: 10.1097/j.pbj.0000000000000257. eCollection 2024 May-Jun.

Composite mantle cell and Burkitt lymphoma: a rare case report

José Guilherme Freitas  1 , Ângelo Rodrigues  2 , Susana Lisboa  3 , José Mário Mariz  1
Affiliations

Composite mantle cell and Burkitt lymphoma: a rare case report

José Guilherme Freitas et al. Porto Biomed J. .
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest

Figures

Figure 1.
Figure 1.
(A) (H&E 40X) biopsy sample from right inguinal mass showing two distinct cell populations: (B) (H&E 200X) on the upper half of the picture, there is a predominance of small cells, with centrocyte-like appearance, consistent with mantle cell lymphoma.
Figure 2.
Figure 2.
(C) (H&E 200X) on the lower half, the cell population is mostly comprised medium size cells with round nuclei containing multiple small nucleoli and apoptosis, compatible with Burkitt lymphoma. (D–G) Immunohistochemistry highlighting the main differences between the two components (D—CD20, E—Bcl-2, F—cyclin D1, G—CD10). FISH analysis showing IGH-CCND1 fusion signals (yellow) in the MCL component (H) and separate red and green signals in the Burkitt component with c-MYC rearrangement (I).
See this image and copyright information in PMC

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