Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr-Jun;15(2):111-116.
doi: 10.4103/japtr.japtr_325_23. Epub 2024 May 6.

Antioxidant potential and polyphenol content in different parts of Graptophyllum pictum extracts

Feda Anisah Makkiyah  1 , Eldiza Puji Rahmi  1 , Rini Anggi Arista  2 , Nelly Marliani  2 , Waras Nurcholis  2   3
Affiliations

Antioxidant potential and polyphenol content in different parts of Graptophyllum pictum extracts

Feda Anisah Makkiyah et al. J Adv Pharm Technol Res. 2024 Apr-Jun.

Abstract

The antioxidant potential of Graptophyllum pictum (wungu leaves), an indigenous shrub plant extensively used in traditional medicine in Indonesia, was investigated in this study. The research focused on a comprehensive evaluation of total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) across various plant parts, including roots, stems, and flowers, which had been underexplored in prior studies. The ethanol extract derived from wungu flowers and leaves demonstrated notable antioxidant potential, characterized by elevated TPC (12.22 ± 0.31 mg GAE/g DW) and FRAP (37.73 ± 1.08 μmol TEAC/g DW) in the ethanol extract of wungu flowers. Similarly, the ethanol extract of wungu leaves showcased a substantial TFC (2.31 ± 0.18 mg QE/g DW) and DPPH (1.12 ± 0.05 μmol TEAC/g DW), surpassing other parts of the wungu plant in the same or different extracts. These findings suggested that ethanol extracts were a promising foundation for herbal medicines with antioxidant properties, highlighting their potential applications in plant breeding programs. Furthermore, the correlation data underscored the significance of the ethyl acetate and ethanol extracts, revealing a robust correlation between TPC, TFC, and FRAP compared to the n-hexane extract.

Keywords: Antioxidant activity; Graptophyllum pictum (L.) griff; polyphenol.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Scatter plot Pearson correlation between (a) total phenolic content (TPC) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) of ethanol extract, (b) TPC and DPPH of n-hexane extract, (c) TPC and DPPH of ethyl acetate extract, (d) TPC and ferric reducing antioxidant power (FRAP) of ethanol extract, (e) TPC and FRAP of n-hexane extract, (f) TPC and FRAP of ethyl acetate extract. TPC: Total phenolic content, DPPH: Diphenyl-1-picrylhydrazyl, FRAP: Ferric-reducing antioxidant power
Figure 2
Figure 2
Scatter plot Pearson correlation between (a) total flavonoid content (TFC) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) of ethanol extract, (b) TFC and DPPH of n-hexane extract, (c) TFC and DPPH of ethyl acetate extract, (d) TFC and ferric-reducing antioxidant power (FRAP) of ethanol extract, (e) TFC and FRAP of n-hexane extract, (f) TFC and FRAP of ethyl acetate extract. TFC: Total flavonoid content, DPPH: Diphenyl-1-picrylhydrazyl, FRAP: Ferric-reducing antioxidant power
See this image and copyright information in PMC

References

    1. Makkiyah F, Rahmi EP, Revina R, Susantiningsih T, Setyaningsih Y. Graptophyllum pictum (L.) Griff. (Syn: Justicia picta Linn.) and its effectiveness: A well-known Indonesian plant. Pharmacogn J. 2021;13:835–8.
    1. Mashaqhbeh H, Alzoubi KH, Khabour OF, Abu-Farha R. Awareness and perception of pharmacy researchers about conflict of interest: A study from the MENA region. J Appl Pharm Sci. 2022;12:148–55. - PMC - PubMed
    1. Hutagalung MSB, Budiono P, Prasetyo SA, Riwanto I, Nugroho EA, Wisnu Y, et al. Phlebotropic effect of Graptophyllum pictum (L.) Griff. on experimental Wistar hemorrhoids. J Biomed Transl Res. 2019;5:1–4.
    1. Rachim S, Kurniawati A, Astuti P. The effect of purple leaf extract (Graptophyllum pictum L. Griff) to the amount of fibroblast in gingiva rat Wistar induced by Porphyromonas gingivalis. Dent J Kedokt Gigi. 2020;14:94–100.
    1. Rikomah S, Fitri N. Ethanolic extract ointment of the Graptophyllum pictum L. Griff leaves as analgesic agent to male white rat. Oceana Biomed J. 2020;3:32–44.