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. 2024 Jun 6:15:1321622.
doi: 10.3389/fendo.2024.1321622. eCollection 2024.

Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

Xueyan Wu #  1   2 , Shuangyuan Wang #  1   2 , Lin Lin #  1   2 , Xiaojing Jia  1   2 , Chunyan Hu  1   2 , Hongyan Qi  1   2 , Hong Lin  1   2 , Ruizhi Zheng  1   2 , Mian Li  1   2 , Yu Xu  1   2 , Min Xu  1   2 , Lulu Chen  3 , Tianshu Zeng  3 , Ruying Hu  4 , Zhen Ye  4 , Lixin Shi  5 , Qing Su  6 , Xuefeng Yu  7 , Li Yan  8 , Tiange Wang  1   2 , Zhiyun Zhao  1   2 , Jie Zheng  1   2 , Guijun Qin  9 , Qin Wan  10 , Gang Chen  11 , Meng Dai  1   2 , Xulei Tang  12 , Zhengnan Gao  13 , Feixia Shen  14 , Xuejiang Gu  14 , Zuojie Luo  15 , Yingfen Qin  15 , Li Chen  16 , Xinguo Hou  16 , Yanan Huo  17 , Qiang Li  18 , Guixia Wang  19 , Yinfei Zhang  20 , Chao Liu  21 , Youmin Wang  22 , Shengli Wu  23 , Tao Yang  24 , Huacong Deng  25 , Jiajun Zhao  26 , Yiming Mu  27 , Guang Ning  1   2 , Weiqing Wang  1   2 , Yufang Bi  1   2 , Yuhong Chen  1   2 , Jieli Lu  1   2
Affiliations

Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

Xueyan Wu et al. Front Endocrinol (Lausanne). .

Abstract

Background: The triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.

Methods: This cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.

Results: Multivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19-2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13-17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09-1.68), 1.27 (1.05-1.54), 1.26 (1.05-1.52), and 1.32 (1.08-1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] ≥2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44-3.87).

Conclusion: The TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women.

Keywords: Chinese population; breast cancer; glucose; insulin resistance; triglyceride.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewers YM and PB declared a shared parent affiliation with the authors JL, XW, SW, LL, XJ, CH, HQ, HL, RZ, ML, YX, MX, TW, ZZ, JZ, MD, GN, WW, YB, YC, YZ, and QS and the reviewer JY declared a shared parent affiliation with the author LY to the handling editor at the time of review.

Figures

Figure 1
Figure 1
Participant flow diagram of this study.
Figure 2
Figure 2
Non-linear dose–response relationship between the TyG index and breast cancer. The solid lines represent a fitted relationship, and the shadows represent the 95% confidence interval. TyG index, triglyceride glucose index.
Figure 3
Figure 3
Association of TyG index per 1 SD increase with breast cancer risk stratified by potential risk factors. TyG index, triglyceride glucose index; OR, odds ratio; 95% CI, 95% confidence interval; BMI, body mass index.
See this image and copyright information in PMC

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