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Review
. 2024 Aug;24(8):415-423.
doi: 10.1007/s11882-024-01156-8. Epub 2024 Jun 21.

The Role of the Microbiome in Allergy, Asthma, and Occupational Lung Disease

Ashley Peer  1 , Derrick R Samuelson  2   3
Affiliations
Review

The Role of the Microbiome in Allergy, Asthma, and Occupational Lung Disease

Ashley Peer et al. Curr Allergy Asthma Rep. 2024 Aug.

Abstract

Purpose of review: The human commensal microbiota is now widely accepted as a key regulator of human health and disease. The composition of the mucosal associated microbiota has been shown to play a critical role in the lung health. The role of the mucosal microbiota in the development and severity of allergy, asthma, and occupational lung disease is only beginning to take shape. However, advances in our understanding of these links have tremendous potential to led to new clinical interventions to reduce allergy, asthma, and occupational lung disease morbidity.

Recent findings: We review recent work describing the relationship and role of the commensal microbiota in the development of allergy, asthma, and occupational lung disease. Our review primarily focuses on occupational exposures and the effects of the microbiome, both in composition and function. Data generated from these studies may lead to the development of interventions targeted at establishing and maintaining a healthy microbiota. We also highlight the role of environmental exposures and the effects on the commensal microbial community and their potential association with occupational lung disease. This review explores the current research describing the role of the human microbiome in the regulation of pulmonary health and disease, with a specific focus on the role of the mucosal microbiota in the development of allergy, asthma, and occupational lung disease.

Keywords: Allergy; Asthma; Exposures; Lung disease; Microbiota.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Changes in commensal microbial communities associated with occupational exposures
See this image and copyright information in PMC

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