The mechanisms in the gut microbiota regulation and type 2 diabetes therapeutic activity of resistant starches

Xiaoqing Li¹, Ruoxin Chen², Jiahui Wen³, Ruya Ji⁴, Xu Chen⁵, Yong Cao⁶, Yigang Yu⁷, Chao Zhao⁸

Affiliations

¹ State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China; Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
² State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China.
³ State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
⁴ Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
⁵ School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
⁶ Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China.
⁷ College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China.
⁸ State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: zhchao@live.cn.

PMID: 38906356
DOI: 10.1016/j.ijbiomac.2024.133279

Review

The mechanisms in the gut microbiota regulation and type 2 diabetes therapeutic activity of resistant starches

Xiaoqing Li et al. Int J Biol Macromol. 2024 Aug.

. 2024 Aug;274(Pt 1):133279.

doi: 10.1016/j.ijbiomac.2024.133279. Epub 2024 Jun 19.

Authors

Xiaoqing Li¹, Ruoxin Chen², Jiahui Wen³, Ruya Ji⁴, Xu Chen⁵, Yong Cao⁶, Yigang Yu⁷, Chao Zhao⁸

Affiliations

¹ State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China; Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
² State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China.
³ State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
⁴ Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
⁵ School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
⁶ Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China.
⁷ College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China.
⁸ State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: zhchao@live.cn.

PMID: 38906356
DOI: 10.1016/j.ijbiomac.2024.133279

Abstract

Resistant starch (RS) can potentially prevent type 2 diabetes through the modulation of intestinal microbiota and microbial metabolites. Currently, it has been wildly noted that altering the intestinal microbial composition and short-chain fatty acids levels can achieve therapeutic effects, although the specific mechanisms were rarely elucidated. This review systematically explores the structural characteristics of different RS, analyzes the cross-feeding mechanism utilized by intestinal microbiota, and outlines the pathways and targets of butyrate, a primary microbial metabolite, for treating diabetes. Different RS types may have a unique impact on microbiota composition and their cross-feeding, thus exploring regulatory mechanisms of RS on diabetes through intestinal flora interaction and their metabolites could pave the way for more effective treatment outcomes for host health. Furthermore, by understanding the mechanisms of strain-level cross-feeding and metabolites of RS, precise dietary supplementation methods targeted at intestinal composition and metabolites can be achieved to improve T2DM.

Keywords: Butyrate; Cross-feeding; Diabetes; Intestinal microbiota; Resistant starch.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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The mechanisms in the gut microbiota regulation and type 2 diabetes therapeutic activity of resistant starches

Affiliations

The mechanisms in the gut microbiota regulation and type 2 diabetes therapeutic activity of resistant starches

Authors

Affiliations

Abstract

Conflict of interest statement

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LinkOut - more resources

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Medical