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Editorial
. 2024 Jul;106(1):9-12.
doi: 10.1016/j.kint.2024.01.032.

Taking the amphoterism out of amphotericin: a wonder drug in the making

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Editorial

Taking the amphoterism out of amphotericin: a wonder drug in the making

Andrew Beenken. Kidney Int. 2024 Jul.
No abstract available

Keywords: amphotericin; cholesterol; ion channels; nephrotoxicity.

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  • Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
    Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Maji A, et al. Nature. 2023 Nov;623(7989):1079-1085. doi: 10.1038/s41586-023-06710-4. Epub 2023 Nov 8. Nature. 2023. PMID: 37938782 Free PMC article.

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