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Review
. 2024 Jun 21;26(1):26.
doi: 10.1007/s12017-024-08794-1.

Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway

Kexin Lin #  1 , Yong Zhang #  1 , Yanyang Shen #  1 , Yiqin Xu  1 , Min Huang  1 , Xuehong Liu  2
Affiliations
Review

Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway

Kexin Lin et al. Neuromolecular Med. .

Abstract

Spinal cord injury (SCI) causes irreversible cell loss and neurological dysfunctions. Presently, there is no an effective clinical treatment for SCI. It can be the only intervention measure by relieving the symptoms of patients such as pain and fever. Free radical-induced damage is one of the validated mechanisms in the complex secondary injury following primary SCI. Hydrogen sulfide (H2S) as an antioxidant can effectively scavenge free radicals, protect neurons, and improve SCI by inhibiting the p38MAPK/mTOR/NF-κB signaling pathway. In this report, we analyze the pathological mechanism of SCI, the role of free radical-mediated the p38MAPK/mTOR/NF-κB signaling pathway in SCI, and the role of H2S in scavenging free radicals and improving SCI.

Keywords: Free radicals; Hydrogen sulfide; Reactive oxygen species; Spinal cord injury; p38MAPK/mTOR/NF-κB signaling pathway.

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