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. 2024 Jun 21;23(1):189.
doi: 10.1186/s12944-024-02179-w.

Association between serum lipid and all-cause mortality in asthmatic populations: a cohort study

Jun Wen #  1 , Rongjuan Zhuang #  1 , Qingliu He #  2   3 , Chengcheng Wei #  3   4 , Mohan Giri  1 , Jing Chi  5
Affiliations

Association between serum lipid and all-cause mortality in asthmatic populations: a cohort study

Jun Wen et al. Lipids Health Dis. .

Abstract

Background: Presently, the majority of investigations primarily evaluate the association between lipid profiles and asthma. However, few investigations explore the connection between lipids and mortality related to the disease. This study aims to explore the association of serum lipids with all-cause mortality within asthmatic adults.

Methods: The investigation included 3233 eligible patients with asthma from the NHANES (2011-2018). The potential associations were explored using three Cox proportional hazards models, restricted cubic splines (RCS), threshold effect models, and CoxBoost models. In addition, subgroup analyses were conducted to investigate these associations within distinct populations.

Results: After controlling all covariables, the Cox proportional hazards model proved a 17% decrease in the probability of death for each increased unit of low-density lipoprotein-cholesterol (LDL-C) (mmol/L). Yet, there was no association seen between blood high-density lipoprotein cholesterol (HDL-C), total cholesterol, or triglyceride and all-cause mortality in asthmatics. The application of RCS and threshold effect models verified an inverse and linear association of LDL-C with all-cause mortality. According to the results from the CoxBoost model, LDL-C exhibited the most substantial impact on the follow-up status of asthmatics among the serum lipids.

Conclusion: Our investigation concluded that in American asthmatic populations, LDL-C levels were inversely and linearly correlated with mortality. However, no independent relationship was found between triglycerides, total cholesterol, or HDL-C and mortality.

Keywords: Asthma; Lipid; Low-density lipoprotein-cholesterol (LDL-C); Mortality; National Health and Nutrition Examination Survey (NHANES); CoxBoost.

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Conflict of interest statement

All authors confirm that there were no financial or business connections that might be seen as potentially causing a conflict of interest during the investigation.

Figures

Fig. 1
Fig. 1
Flow diagram of selecting populations for analysis
Fig. 2
Fig. 2
Association of serum LDL-C with all-cause mortality in asthmatics. The red solid line and red area correspond to the HR and their corresponding 95%CI, separately
Fig. 3
Fig. 3
The CoxBoost model assessed the positive and negative effects size of serum lipids in relation to the follow-up status
Fig. 4
Fig. 4
(A) Kaplan-Meier survival analysis for asthamtic populations based on LDL-C of tertile groups. (B) Figure B was a thumbnail of Figure A.T1-T3: LDL-C is grouped by tertiles
See this image and copyright information in PMC

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