Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 Jun 22;52(1):98.
doi: 10.1007/s00240-024-01590-3.

Predictive value of inflammatory markers for the spontaneous passage of Ureteral stones: a comprehensive systematic review with meta analysis

Rawa Bapir  1   2   3 , Saman S Fakhralddin  1   2   4 , Ismaeel Aghaways  4 , Bryar O Muhammed  5 , Hawbash M Rahim  3   6 , Fattah H Fattah  2   4 , Barzan O Ismael  5 , Rebaz E Ali  2 , Karokh F Hamahussein  2 , Fahmi Hussein Kakamad  7   8 , Rawezh Q Salih  2   3   9 , Shvan H Mohammed  3 , Berun A Abdalla  2   3
Affiliations
Meta-Analysis

Predictive value of inflammatory markers for the spontaneous passage of Ureteral stones: a comprehensive systematic review with meta analysis

Rawa Bapir et al. Urolithiasis. .

Abstract

Urolithiasis is a common disease that affects approximately one-fifth of the global population. This systematic review explores the predictive role of inflammatory markers for the spontaneous passage of ureteral stones. The literature was systematically searched via Google Scholar, PubMed/MEDLINE, the Cochrane Library, Science Direct, CINAHL, Web of Science, and EMBASE databases to identify papers published until 2023. Overall, 26 articles were identified, of which 10 were excluded. The remaining 16 papers reported 2,695 patients (1,723 males and 972 females), with 1,654 (61.37%) experiencing spontaneous stone passage (SSP) and 1,041 (38.63%) not experiencing it (non-SSP). Stones located in the upper part of the ureter were less likely to pass spontaneously (152/959, 15.94% in the SSP group vs. 180/546, 32.48% in the non-SSP group; p < 0.001). Mid-ureteral stones were present in 180/959 (18.75%) of the SSP group compared to 84/546 (14.52%) of the non-SSP group (p = 0.0974). Lower ureteral stones were more likely to pass spontaneously, with 627/959 (63.31%) in the SSP group compared to 282/546 (49.36%) in the non-SSP group (p < 0.001). No significant correlation was found between most inflammatory markers and SSP (p > 0.05). However, procalcitonin levels were lower in the SSP group compared to the non-SSP group (132.7 ± 28.1 vs. 207 ± 145.1, respectively) (p < 0.001). This systematic review has revealed that except procalcitonin, most inflammatory markers do not offer significant predictive capability for ureteral SSP.

Keywords: Inflammatory markers; Procalcitonin; Ureter; Urolithiasis.

PubMed Disclaimer

References

    1. Abou Heidar, Nassib M, Labban G, Bustros, Nasr R (2020) Inflammatory serum markers predicting spontaneous ureteral stone passage. Clin Exp Nephrol 24:277–283 inverse - DOI - PubMed
    1. Mohammad E, Jasim KM, Abbas AF, Hassan, Alaa Abdulqader Abdulrazaq (2018) Serum c-reactive protein as a predictive factor for spontaneous stone passage in patients with 4 to 8 mm distal ureteral stones. Int Surg J 5(4):1195–1200 - DOI
    1. Sfoungaristos S, Kavouras A, Katafigiotis I, Perimenis P (2012) Role of white blood cell and neutrophil counts in predicting spontaneous stone passage in patients with renal colic. BJU international 110, no. 8b : E339-E345
    1. Hada A, Yadav SS, Tomar V, Priyadarshi S, Agarwal N, Anil Gulani (2018) Assessment of factors affecting the spontaneous passage of lower ureteric calculus on the basis of lower ureteric calculus diameter, density, and plasma C-reactive protein level. Urol Annals 10(3):302 - DOI
    1. Puntub A, Lerdpraiwan W Relationship Between the Spontaneous Passage Rates of Ureteral Stones Less Than 10 Mm and Serum C-Reactive Protein Levels, White Blood Cell Count and Neutrophil Percentages. Insight Urol 39 (2)(2018):42–49

LinkOut - more resources