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Review
. 2024 Oct;49(10):102716.
doi: 10.1016/j.cpcardiol.2024.102716. Epub 2024 Jun 22.

Outcomes of Ultrafiltration in community-based hospitals

Viswanath R Chinta  1 , Neelima P Theella  2 , Joel M Raja  3 , Aranyank Rawal  3 , Anandbir Bath  4 , David Jones  3 , Atif Ibrahim  5 , Abdul Aziz A Asbeutah  3 , Adedayo A Adeboye  3 , Oguz Akbilgic  6 , Rami N Khouzam  7 , James J Stamper  8 , John L Jefferies  9
Affiliations
Review

Outcomes of Ultrafiltration in community-based hospitals

Viswanath R Chinta et al. Curr Probl Cardiol. 2024 Oct.

Abstract

Objective: We sought to examine outcomes of ultrafiltration in real world community-based hospital settings.

Background: Ultrafiltration (UF) is an accepted therapeutic option for advanced decompensated heart failure (ADHF). the feasibility of UF in a community hospital setting, by general cardiologists in a start-up program had not been objectively evaluated.

Methods: We retrospectively analyzed the first-year cohort of ADHF patients treated with UF from 10/1/2019 to 10/1/2020, which totaled 30 patients, utilizing the CHF Solutions Aquadex FlexFlow™ System with active UF rate titration.

Results: Baseline patient characteristics were similar to RCTs: mean age 63, 73 % male; 27 % female; 53 % Caucasian; 47 % African American; 77 % had LVEF ≤ 40. The baseline mean serum creatinine (Cr) was 1.84 ±0.62 mg/dL, mean GFR of 36.95 ±9.60 ml/min. HF re-admission rates were not significantly different than prior studies (17.2 % at 30 d, 23.3 % at 60 d, but in our cohort, per patient HF re-admission rates were reduced significantly by 60 d (0.30 p = 0.017).

Conclusion: Our analysis showed success with UF in mainstream setting with reproducible results of significant volume loss without adverse renal effect, mitigation of recurrent Hdmissions, and remarkable subjective clinical benefit.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: John L. Jefferies, MD, MPH, Oguz Akbilgic, DBA, PhD reports financial support was provided by Nuwellis. John L. Jefferies, MD, MPH reports a relationship with Nuwellis Inc that includes: consulting or advisory and speaking and lecture fees. Oguz Akbilgic, DBA, PhD reports a relationship with Nuwellis Inc that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.