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. 2024 Jun 24;24(4):116.
doi: 10.1007/s10142-024-01395-y.

Reviving resilience: MEcPP-mediated ASK1-IMPα-9-TRP2 stress-responsive module

Hamza Sohail  1 , Iqra Noor  1 , Xuewen Xu  1 , Rahat Sharif  1 , Xuehao Chen  1 , Xiaodong Yang  2
Affiliations

Reviving resilience: MEcPP-mediated ASK1-IMPα-9-TRP2 stress-responsive module

Hamza Sohail et al. Funct Integr Genomics. .

Abstract

Chloroplasts are not only critical photosynthesis sites in plants, but they also participate in plastidial retrograde signaling in response to developmental and environmental signals. MEcPP (2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate) is an intermediary in the methylerythritol phosphate (MEP) pathway in chloroplasts. It is a critical precursor for the synthesis of isoprenoids and terpenoid derivatives, which play crucial roles in plant growth and development, photosynthesis, reproduction, and defense against environmental constraints. Accumulation of MEcPP under stressful conditions triggers the expression of IMPα-9 and TPR2, contributing to the activation of abiotic stress-responsive genes. In this correspondence, we discuss plastidial retrograde signaling in support of a recently published paper in Molecular Plant (Zeng et al. 2024). We hope that it can shed more insight on the retrograde signaling cascade.

Keywords: Abiotic stress; IMPα-9; MEcPP; Retrograde signaling; TPR2.

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References

    1. Agrawal V, Singh V, Tripathi BN (2023) Components and processes involved in retrograde signaling from chloroplast to nucleus. Physiol Plant 175:1–11 - DOI
    1. Benn G, Bjornson M, Ke H et al (2016) Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3. Proc Natl Acad Sci U S A 113:8855–8860 - DOI - PubMed - PMC
    1. Bolle C, Sopory S, Lubberstedt T et al (1994) The role of plastids in the expression of nuclear genes for thylakoid proteins studied with chimeric [beta]-glucuronidase gene fusions. Plant Physiol 105:1355–1364 - DOI - PubMed - PMC
    1. de Souza A, Wang J-Z, Dehesh K (2017) Retrograde signals: integrators of interorganellar communication and orchestrators of plant development. Annu Rev Plant Biol 68:85–108 - DOI - PubMed
    1. Jiang J, Dehesh K (2021) Plastidial retrograde modulation of light and hormonal signaling: an odyssey. New Phytol 230:931–937 - DOI - PubMed

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