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Case Reports
. 2024 Jun 21;11(6):e01394.
doi: 10.14309/crj.0000000000001394. eCollection 2024 Jun.

Primary Mediastinal Large B-Cell Lymphoma Presenting as Acute Pancreatitis

Karolina Krawczyk  1 , Angelika Kwak  2 , Christopher Kujalowicz  2 , Karolina Truszkowska  2 , Vincent Biank  3 , Natalie Kamberos  4
Affiliations
Case Reports

Primary Mediastinal Large B-Cell Lymphoma Presenting as Acute Pancreatitis

Karolina Krawczyk et al. ACG Case Rep J. .

Abstract

Pancreatitis is an inflammatory pancreatic disease; common etiologies include infection, anatomic abnormalities, biliary, inborn errors of metabolism, trauma, and rarely malignancy. Primary mediastinal large B-cell lymphoma commonly presents in younger women with principally mediastinal involvement. We report the first documented case of a pediatric patient presenting with acute pancreatitis secondary to metastatic primary mediastinal large B-cell lymphoma. Since diagnosis, the patient underwent a combination of chemotherapy and immunotherapy treatments, and the tumor burden had decreased significantly. Malignancy is a rare documented presentation of acute pancreatitis in the pediatric population, and it should be included in a broad differential diagnosis.

Keywords: pediatric malignancies; pediatric pancreatitis; primary mediastinal large B-cell lymphoma.

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Figures

Figure 1.
Figure 1.
Abdominal magnetic resonance shows a mixed solid/cystic pancreatic head mass.
Figure 2.
Figure 2.
Abdominal computed tomography shows a mediastinal mass with internal necrotic change.
See this image and copyright information in PMC

References

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