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Review
. 2024 Sep;82(3):1825-1836.
doi: 10.1007/s12013-024-01381-y. Epub 2024 Jun 24.

Research Progress on the Role of Ubiquitination in Eye Diseases

Zhongyu Ma  1 , Jiawen Hao  1 , Zhaohui Yang  1 , Miao Zhang  1 , Jizhao Xin  1 , Hongsheng Bi  2   3   4 , Dadong Guo  5   6   7
Affiliations
Review

Research Progress on the Role of Ubiquitination in Eye Diseases

Zhongyu Ma et al. Cell Biochem Biophys. 2024 Sep.

Abstract

The occurrence and development of ophthalmic diseases are related to the dysfunction of eye tissues. Ubiquitin is an important form of protein post-translational modification, which plays an essential role in the occurrence and development of diseases through specific modification of target proteins. Ubiquitination governs a variety of intracellular signal transduction processes, including proteasome degradation, DNA damage repair, and cell cycle progression. Studies have found that ubiquitin can play a role in eye diseases such as cataracts, glaucoma, keratopathy, retinopathy, and eye tumors. In this paper, the role of protein ubiquitination in eye diseases was reviewed.

Keywords: Cataract; Keratopathy; Ocular tumor; Protein ubiquitination; Retinopathy.

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