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Comment
. 2024 Jul 2;121(27):e2409667121.
doi: 10.1073/pnas.2409667121. Epub 2024 Jun 24.

The biophysical landscape of viral evolution

Claus O Wilke  1
Affiliations
Comment

The biophysical landscape of viral evolution

Claus O Wilke. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
Conformations of the SARS-CoV2 spike protein. The spike protein forms a trimer, and the receptor-binding domain (RBD) for each protein in the trimer can be in either the down or up conformation. Only the up conformation can bind to the ACE2 receptor, and it is also more immunogenic. (A) All three chains are in the down conformation. (B) One chain is in the up conformation and two are in the down conformation. (C) All three chains are in the up conformation. Visualizations of the SARS-CoV2 spike protein made with the SpikePro web server (7).
See this image and copyright information in PMC

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