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. 2024 Aug;47(8):2064-2074.
doi: 10.1038/s41440-024-01705-8. Epub 2024 Jun 24.

Associations of combined genetic and lifestyle risks with hypertension and home hypertension

Masato Takase  1 , Takumi Hirata  2   3 , Naoki Nakaya  1   2 , Tomohiro Nakamura  2   4 , Mana Kogure  1   2 , Rieko Hatanaka  1   2 , Kumi Nakaya  1   2 , Ippei Chiba  1   2 , Ikumi Kanno  1   2 , Kotaro Nochioka  1   2   5 , Naho Tsuchiya  1   2 , Akira Narita  1   2 , Hirohito Metoki  1   6 , Michihiro Satoh  1   6 , Taku Obara  1   2 , Mami Ishikuro  1   2 , Hisashi Ohseto  1   2 , Akira Uruno  2 , Tomoko Kobayashi  1   2   5 , Eiichi N Kodama  2   7 , Yohei Hamanaka  2 , Masatsugu Orui  1   2 , Soichi Ogishima  1   2 , Satoshi Nagaie  1   2 , Nobuo Fuse  1   2 , Junichi Sugawara  1   2   5   8 , Shinichi Kuriyama  1   2   7 , Gen Tamiya  1   2   9 , Atsushi Hozawa  10   11 , Masayuki Yamamoto  1   2 ; ToMMo investigators
Affiliations

Associations of combined genetic and lifestyle risks with hypertension and home hypertension

Masato Takase et al. Hypertens Res. 2024 Aug.

Abstract

No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.

Keywords: Hypertension; Lifestyle risk reduction; Polygenic risk score.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of study participants
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