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. 2024 Aug;38(8):4496-4504.
doi: 10.1007/s00464-024-10989-3. Epub 2024 Jun 24.

Long-term results after transoral outlet reduction (TORe) of the gastrojejunal anastomosis for secondary weight regain and dumping syndrome after Roux-en-Y gastric bypass

Jonathan Lovis #  1 , Stefan Fischli #  2 , Francesco Mongelli  3 , Julia Mühlhäusser  1 , Patrick Aepli  4 , Martin Sykora  5 , Andreas Scheiwiller  1 , Jürg Metzger  1 , Jörn-Markus Gass  6   7
Affiliations

Long-term results after transoral outlet reduction (TORe) of the gastrojejunal anastomosis for secondary weight regain and dumping syndrome after Roux-en-Y gastric bypass

Jonathan Lovis et al. Surg Endosc. 2024 Aug.

Abstract

Background: Bariatric surgery has been proven to be the most effective therapy for obesity and Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed procedure. However, weight regain and dumping syndrome occur over time. The transoral outlet reduction (TORe) procedure using an endoscopic suturing device may be an option to treat these conditions. We aimed to analyze outcome parameters and long-term results for this endoscopic technique.

Methods: A retrospective data analysis of patients who underwent TORe using an endoscopic suturing system at our institution from January 2015 to December 2020 was performed. A total of 71 subjects were included. Forty-five patients received the intervention for weight regain, 9 for dumping syndrome and 17 for both. The primary endpoint was weight stabilization or weight loss for subjects with weight regain, and resolution of symptoms for those with dumping syndrome. Secondary endpoints were intraoperative complications, procedure time, length of hospital stay and diameter of gastrojejunal anastomosis 1 year post-intervention.

Results: The median size of the gastrojejunal anastomosis was estimated at 30 mm before intervention, and after performing a median of 3 endoscopic sutures, the median estimated gastrojejunal anastomosis width was reduced to 9.5 mm. Eight perioperative complications occurred. Overall mean follow-up was 26.5 months. All interventions achieved weight stabilization or weight loss or resolution of dumping symptoms within the first 3 months, 98.2% at 12 months, 91.4% at 24 months and 75.0% at 48 months. In 22/26 subjects a persisting improvement of dumping syndrome was achieved.

Conclusions: TORe is a safe and effective procedure in the treatment of patients with dumping syndrome after laparoscopic RYGB, the effect on weight stabilization is less significant. A prospective randomized trial should be conducted to compare the effects of TORe with other surgical methods like banding the gastrojejunal anastomosis.

Keywords: Bariatric surgery; Dumping syndrome; Endoscopy; Roux-en-Y gastric bypass; Secondary weight regain; Transoral outlet reduction.

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Conflict of interest statement

Jonathan Lovis, Stefan Fischli, Francesco Mongelli, Julia Mühlhäusser, Patrick Aepli, Martin Sykora, Andreas Scheiwiller, Jürg Metzger, Jörn-Markus Gass have no conflicts of interest or financial ties to disclose.

Figures

Fig. 1
Fig. 1
Patients with weight loss or weight maintained during follow-up
Fig. 2
Fig. 2
% Total Weight Loss during follow-up
Fig. 3
Fig. 3
BMI during follow-up
See this image and copyright information in PMC

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