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Case Reports
. 2024 May 24;16(5):e61013.
doi: 10.7759/cureus.61013. eCollection 2024 May.

Challenges of Diagnosis: Periampullary Mass-Induced Obstructive Jaundice in a Young Woman

Anusha Gupta  1 , Vijendra Kirnake  1 , Vishal Padwale  1 , Aishwarya Gupta  2 , Sourav Chaturvedi  3
Affiliations
Case Reports

Challenges of Diagnosis: Periampullary Mass-Induced Obstructive Jaundice in a Young Woman

Anusha Gupta et al. Cureus. .

Abstract

Periampullary cancers, which include pancreatic adenocarcinoma, ampullary cancer, distal cholangiocarcinoma, and duodenal cancer, present diagnostic and management challenges due to their aggressive nature and nonspecific symptoms. We describe a case of a female patient, age 20, who had obstructive jaundice brought on by a periampullary tumor. Despite difficulties in diagnosis and treatment, including failed endoscopic retrograde cholangiopancreatography (ERCP), the patient underwent a successful pancreaticoduodenectomy (Whipple's resection), and subsequent immunohistochemistry revealed adenocarcinoma with a mixed immunophenotype expressing duodenal and pancreatic markers. This example emphasizes the significance of taking young patients' periampullary tumors into account, the difficulties in diagnosing them, and the possibility of effective surgical surgery throughout this age range.

Keywords: adenocarcinoma; immunohistochemistry; obstructive jaundice; pancreaticoduodenectomy; periampullary cancer; young adult.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. ERCP image showing slightly deformed ampulla
ERCP: Endoscopic retrograde cholangiopancreatography
Figure 2
Figure 2. ERCP image showing attempted cannulation of the ampulla
ERCP: Endoscopic retrograde cholangiopancreatography
Figure 3
Figure 3. Moderately differentiated adenocarcinoma of the periampullary region (A) and distal CBD (B)
CBD: Common bile duct
See this image and copyright information in PMC

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