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. 2024 Jul;30(7):1493-1495.
doi: 10.3201/eid3007.240354.

World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme, Cambodia, 2023

Vichea Ouk, Heng Lon Say, Mot Virak, Serakea Deng, Rebekah Frankson, Robert McDonald, Ellen N Kersh, Teodora Wi, Ismael Maatouk, Sebastiaan van Hal, Monica M Lahra; EGASP Cambodia working group
Collaborators

World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme, Cambodia, 2023

Vichea Ouk et al. Emerg Infect Dis. 2024 Jul.

Abstract

To determine antimicrobial susceptibility of Neisseria gonorrhoeae, we analyzed phenotypes and genomes of 72 isolates collected in Cambodia in 2023. Of those, 9/72 (12.5%) were extensively drug resistant, a 3-fold increase from 2022. Genomic analysis confirmed expansion of newly emerging resistant clones and ongoing resistance emergence across new phylogenetic backbones.

Keywords: Antimicrobial resistance; Cambodia; Neisseria gonorrhoeae; World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme; bacteria; sexually transmitted infections; surveillance.

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Figures

Figure
Figure
Circular midpoint rooted phylogeny of sequences from Neisseria gonorrhoeae isolates collected by the World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme, Cambodia, 2022–2023. Associated metadata, year of isolation, MLST, and presence or absence of elevated MICs for CRO are depicted in concentric rings. White cells in the 3 rings correspond with the tree tip belonging to isolate FC428, the first penA-60.001-containing ceftriaxone-resistant isolate documented in Japan in 2015 (6). CRO, ceftriaxone; MLST, multilocus sequence type.
See this image and copyright information in PMC

References

    1. World Health Organization. Enhanced Gonococcal Surveillance Programme general protocol [cited 2022 Jan 20]. https://www.who.int/publications/i/item/9789240021341
    1. Ouk V, Pham CD, Wi T, van Hal SJ, Lahra MM. EGASP Cambodia working group. The Enhanced Gonococcal Surveillance Programme, Cambodia. Lancet Infect Dis. 2023;23:e332–3. - PubMed
    1. Maubaret C, Caméléna F, Mrimèche M, Braille A, Liberge M, Mainardis M, et al. Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023. Euro Surveill. 2023;28:2300456. - PMC - PubMed
    1. Berçot B, Caméléna F, Mérimèche M, Jacobsson S, Sbaa G, Mainardis M, et al. Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022. Euro Surveill. 2022;27:2200899. - PMC - PubMed
    1. van der Veen S. Global transmission of the penA allele 60.001–containing high-level ceftriaxone-resistant gonococcal fc428 clone and antimicrobial therapy of associated cases: a review. Infectious Microbes & Diseases. 2023;5:13–20.

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