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. 2024 Jun 25.
doi: 10.1097/INF.0000000000004443. Online ahead of print.

CENTRAL NERVOUS SYSTEM INFECTION BY GROUP A STREPTOCOCCUS IN CHILDREN IN SPAIN (2019-2023)

Elvira Cobo-Vázquez  1   2 , David Aguilera-Alonso  2   3   4 , Victoria Rello-Saltor  5 , Anna Gamell  6 , Isabel Mellado-Sola  7 , Manuel Oltra-Benavent  8 , Laura Martín-Pedraz  9 , Ángela Manzanares-Casteleiro  10 , Jaime Carrasco-Colom  11 , Eloisa Cervantes  6 , Francisco Sanz-Santaeufemia  12 , Elena Colino-Gil  13 , Beatriz Jiménez-Montero  14 , Beatriz Soto  15 , Cristina Calvo  4   7 , Jesús Saavedra-Lozano  3   4   16 ; PedGAS-net Working Group
Affiliations

CENTRAL NERVOUS SYSTEM INFECTION BY GROUP A STREPTOCOCCUS IN CHILDREN IN SPAIN (2019-2023)

Elvira Cobo-Vázquez et al. Pediatr Infect Dis J. .

Abstract

Central nervous system infections in children caused by group A Streptococcus are rare. This study, conducted across 52 hospitals in Spain from 2019 to 2023, identified 32 cases of central nervous system infections in children caused by group A Streptococcus, with a significant increase from October 2022 onward (1.1% vs. 5.9%, P = 0.002). Half required pediatric intensive care unit admission, 12.5% exhibited sequelae and the mortality rate was 6.2%. Mastoiditis was the predominant primary infection.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

    1. Guy R, Henderson KL, Coelho J, et al. Increase in invasive group A streptococcal infection notifications, England, 2022. Euro Surveill. 2023;28:2200942.
    1. Van Kempen EB, Bruijning-Verhagen PCJ, Borensztajn D, et al. Increase in invasive group a streptococcal infections in children in the Netherlands, a survey among 7 hospitals in 2022. Pediatr Infect Dis J. 2023;42:e122–e124.
    1. Cobo-Vázquez E, Aguilera-Alonso D, Carrasco-Colom J, et al.; PedGAS-net Working Group. Increasing incidence and severity of invasive group A streptococcal disease in Spanish children in 2019-2022. Lancet Reg Health Eur. 2023;27:100597.
    1. Boeddha NP, Atkins L, de Groot R, et al.; EUCLIDS consortium. Group A streptococcal disease in paediatric inpatients: a European perspective [published correction appears in Eur J Pediatr. 2023 Jan 23]. Eur J Pediatr. 2023;182:697–706.
    1. Link-Gelles R, Toews KA, Schaffner W, et al. Characteristics of intracranial group A streptococcal infections in US children, 1997-2014. J Pediatr Infect Dis Soc. 2020;9:30–35.

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