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Review
. 2024 Jul:102-103:4-16.
doi: 10.1016/j.semcancer.2024.06.001. Epub 2024 Jun 23.

RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer

Cameron P Bracken  1 , Gregory J Goodall  2 , Philip A Gregory  3
Affiliations
Free article
Review

RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer

Cameron P Bracken et al. Semin Cancer Biol. 2024 Jul.
Free article

Erratum in

Abstract

Epithelial-mesenchymal transition (EMT) is a major contributor to metastatic progression and is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are tightly controlled by non-coding RNAs - including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) - that collectively have major impacts on gene expression and resulting cellular states. While miRNAs are the best characterised regulators of EMT and TGF-β signaling and the miR-200-ZEB1/2 feedback loop plays a central role, important functions for lncRNAs and circRNAs are also now emerging. This review will summarise our current understanding of the roles of non-coding RNAs in EMT and TGF-β signaling with a focus on their functions in cancer progression.

Keywords: CircRNA; EMT; LncRNA; MiR-200; MiRNA; TGF-β.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that there are no conflicts of interest.

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