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. 2024 Jun 25;25(6):143.
doi: 10.1208/s12249-024-02833-7.

Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals

Patric Müller  1 , Achim Sack  1 , Jens Dümler  1 , Michael Heckel  1   2 , Tim Wenzel  3   4 , Teresa Siegert  3 , Sonja Schuldt-Lieb  5 , Henning Gieseler  4 , Thorsten Pöschel  6
Affiliations

Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals

Patric Müller et al. AAPS PharmSciTech. .

Abstract

The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals. Consequently, visual quality control of the product is imperative. However, this procedure is not only time-consuming and labor-intensive but also expensive and prone to errors. In this paper, we present an approach for fully automated, non-destructive inspection of freeze-dried pharmaceuticals, leveraging robotics, computed tomography, and machine learning.

Keywords: X-ray tomography; freeze-drying; lyopohilisate; non-destructive inspection.

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References

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