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Meta-Analysis
. 2025 Jan;57(1):4-11.
doi: 10.23822/EurAnnACI.1764-1489.351. Epub 2024 Jun 26.

Impact of asthma on severe food-induced allergic reactions: a systematic review and meta-analysis

M B Cilona  1 , G A Ramirez  2 , C Asperti  1 , A Ferlito  1 , G Benanti  1 , S Nannipieri  1 , R M Abdul Hadi  3 , C Capellini  3 , L Dagna  1   3 , M Cottini  4 , M-R Yacoub  1
Affiliations
Meta-Analysis

Impact of asthma on severe food-induced allergic reactions: a systematic review and meta-analysis

M B Cilona et al. Eur Ann Allergy Clin Immunol. 2025 Jan.

Abstract

Background. Food allergy can range from mild to severe, life-threatening reactions with various symptoms and organ involvement. The impact of asthma on severe food-induced allergic reactions is not completely understood. In the hypothesis that asthma increases the risk of severe food-induced allergic reactions, the aim of this study is to compare the incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma. Methods. We performed a systematic research on electronic databases, including PubMed, Scopus and Web of Science. Observational studies, studies reporting medical characteristics of patients diagnosed with food allergy and studies reporting medical history of patients with allergic reactions were included. The primary outcome was the incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma. Results. Eight studies with a total of 90,367 patients met the inclusion criteria and were included, with a total population of 28,166 of patients with food allergy. The incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma was increased (OR 1.28; 95%CI 1.03-1.59; p = 0.03; I2 = 59%). Conclusions. Individuals with both food allergy and asthma are at high risk of severe, potentially fatal allergic reactions. Healthcare professionals should prioritize prevention and management strategies for these subjects. Patients with asthma and food allergy are at increased risk of potentially fatal food-induced allergic reactions. Optimal management of both diseases is nec-essary to prevent potentially life-threatening events. Study registration. The protocol of this review was registered in PROSPERO (CRD42023448293).

Keywords: anaphylaxis; asthma; food allergy; risk factor; severe allergic reactions.

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